Results 211 to 220 of about 2,815,174 (287)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Vaccination against swine enzootic pneumonia in field conditions: effect on clinical, pathological, zootechnical and economic parameters [PDF]

, 2000
F. J. Pallarés, S. Gómez, G. Ramis, Juan Seva, Antonio Muñoz   +4 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

P4.07E.04 Pathological Grading of Early-Stage Lung Cancers Through CT-to-PET Translation and Co-Learning Model [PDF]

Hui Zhou, Zhichao Huang, Mingcen Weng, Lei Yao, Wenlong Zhan, Miao Li   +5 more
openalex   +1 more source

Pathological findings in suspected cases of e-cigarette, or vaping, product use-associated lung injury (EVALI): a case series

, 2020
Sarah Reagan-Steiner, Joy Gary, Eduard Matkovic, Jana M. Ritter, Wun‐Ju Shieh, Roosecelis B. Martines, Angela Werner, Ruth Lynfield, Stacy Holzbauer, Hannah Bullock, Amy M. Denison, Julu Bhatnagar, Brigid C. Bollweg, Mitesh Patel, Mary E. Evans, Brian A. King, Dale A. Rose, Grant Baldwin, Christopher M. Jones, Vikram Krishnasamy, Peter A. Briss, David N. Weissman, Dana Meaney‐Delman, Sherif R. Zaki, Tara C. Jatlaoui, Emilia H. Koumans, Emily Kiernan, Emily E. Petersen, Mateusz P. Karwowski, Liza Valentín-Blasini, Benjamin C. Blount, Kristin J. Cummings, Isaac Ghinai, Kenneth S. Feder, Eden V. Wells, George Turabelidze, P. D. Byers, Lauren J. Tanz, Kristen Navarette, Kirtana Ramadugu, Courtney Dewart, Jeffrey Miller, Kelly Squires, Lily Marsden, Chris Fields   +44 more
openalex   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Perioperative Pembrolizumab in Locally Advanced Melanoma: A Real-world Single-centre Retrospective Study.

Acta Derm Venereol
Goller S, Dege T, Schummer P, Haug L, Meir M, Gehrke T, Klein D, Goebeler M, Kneitz H, Schilling B, Gesierich A, Glutsch V.   +11 more
europepmc   +1 more source

Comparison of radiological and pathological tools to assess response to neoadjuvant treatment in resected pancreatic ductal adenocarcinoma patients. [PDF]

Ther Adv Med Oncol
Jenvrin A, Sartoris R, Dokmak S, Védie AL, Laurent L, Tihy M, Sauvanet A, Rebours V, Ronot M, Bongrain C, Couvelard A, Cros J, de Mestier L.   +12 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source