Results 161 to 170 of about 1,686,445 (282)

Implementation of the Diagnostic Pathfinder, an Internet-Based Tool to Teach Clinical Pathology in Diverse Educational Settings

, 2003
Those of us who teach clinical pathology to veterinary students are continually exploring more effective ways to help students master the application of laboratory medicine to the solution of clinical problems.
Young, Karen, Vermeer, Pamela, Wood, R. Darren, Preast, Vanessa, Danielson, Jared, Christopher, Mary, Pion, Paul, Bender, Holly, Andreasen, Claire, Mills, Eric, George, Jeanne   +10 more
core  

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Clinician Perspectives on Digital and Computational Pathology: Clinical Benefits, Concerns, and Willingness to Adopt. [PDF]

Diagnostics (Basel)
Aggarwal C, Desai A, McConnell N, Cadirov N, Gustavsen G, Agarwal A, Chehab N, Kotapati S, Patel N.   +8 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Preliminary development and validation of the Eating Pathology Clinical Outcomes Tracker. [PDF]

Psychol Assess
Forbush KT, Chen Y, Joo S, Chapa DAN, Hagan KE, Richson BN, Johnson-Munguia S, Christensen Pacella KA, Bottera AR, Thomeczek ML, Bohrer BK, Perko V, Negi S, Sharma AR, Like EE, Morgan RW, Vanzhula IA, Tregarthen J, Palacios J, Gould SR.   +19 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Case of Combined Corticobasal Degeneration and Alzheimer's Disease Pathology: Clinical Presentation, and Diagnosis. [PDF]

Dement Neurocogn Disord
Baek S, Chae SY, Kim JS, Kim HJ.
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Editorial: Epilepsy and Alzheimer's disease: shared pathology, clinical presentations, and targets for treatment. [PDF]

Front Neurol
Leeman-Markowski B, Chin J, Leitner D, Vossel K.   +3 more
europepmc   +1 more source