Results 161 to 170 of about 7,324,524 (245)

Clinician Perspectives on Digital and Computational Pathology: Clinical Benefits, Concerns, and Willingness to Adopt. [PDF]

Diagnostics (Basel)
Aggarwal C, Desai A, McConnell N, Cadirov N, Gustavsen G, Agarwal A, Chehab N, Kotapati S, Patel N.   +8 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Transplantation of Human Peripheral Stem and Progenitor Cells to Humanized Mouse Model for Systemic Lupus Erythematosus

Journal of Blood Medicine
Syahrul Chilmi, Dina Fauziah, Matthew Brian Khrisna, Ifa Fauziah, Friska Supriyanto, Kusworini Handono, Kevin Reinaldo Sunjaya, Wimardy Leonard Wijaya, Mustofa Aidid, Hani Susianti Clinical Pathology Department, Faculty of Medicine Brawijaya University ...
Chilmi S, Fauziah D, Khrisna MB, Fauziah I, Supriyanto F, Handono K, Sunjaya KR, Wijaya WL, Aidid M, Susianti H   +9 more
doaj  

Preliminary development and validation of the Eating Pathology Clinical Outcomes Tracker. [PDF]

Psychol Assess
Forbush KT, Chen Y, Joo S, Chapa DAN, Hagan KE, Richson BN, Johnson-Munguia S, Christensen Pacella KA, Bottera AR, Thomeczek ML, Bohrer BK, Perko V, Negi S, Sharma AR, Like EE, Morgan RW, Vanzhula IA, Tregarthen J, Palacios J, Gould SR.   +19 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

A Case of Combined Corticobasal Degeneration and Alzheimer's Disease Pathology: Clinical Presentation, and Diagnosis. [PDF]

Dement Neurocogn Disord
Baek S, Chae SY, Kim JS, Kim HJ.
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Editorial: Epilepsy and Alzheimer's disease: shared pathology, clinical presentations, and targets for treatment. [PDF]

Front Neurol
Leeman-Markowski B, Chin J, Leitner D, Vossel K.   +3 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source