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The molecular pathology of rosacea [PDF]
Rosacea is a common and chronic inflammatory skin disease that affects over 10 million Americans. Although the phenotypes of rosacea are clinically heterogeneous, they are all related by the presence of chronic facial skin inflammation. Until recently, the pathophysiology of this disease has been poorly understood and limited to descriptions of factors
Kenshi, Yamasaki, Richard L, Gallo
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Molecular Pathology of Lewy Body Diseases [PDF]
Lewy body diseases are characterized by the presence of Lewy bodies, alphasynuclein(AS)-positive inclusions in the brain. Since their main component is conformationally modified AS, aggregation of the latter is thought to be a key pathogenic event in ...
Domingo-Sàbat, Montse +5 more
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Comprehensive understanding of molecular principles in cancer and the diversification of oncological therapy promise individual therapeutic concepts, which have not yet found their way into urogenital cancer therapy.
Warrick, Joshua I. +43 more
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Initiation and spreading of Tau pathology. is β-Amyloid the only key? [PDF]
Neurodegenerative diseases associated with dementia affect 5-10 % of individuals over the age of 65 in the Western world and represent one of the main health-related socioeconomic burdens.
Clavaguera, Florence
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Osteoporosis: Molecular Pathology, Diagnostics, and Therapeutics
Osteoporosis is a major public health concern affecting millions of people worldwide and resulting in significant economic costs. The condition is characterized by changes in bone homeostasis, which lead to reduced bone mass, impaired bone quality, and ...
Babapelumi Adejuyigbe +3 more
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Comprehensive management of medulloblastoma based on revised molecular risk stratification
Medulloblastoma is the most common malignant central nervous system tumor in children. The current treatment approach primarily consists of surgery combined with adjuvant radiotherapy and chemotherapy.
LIU Hai-long +2 more
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The molecular pathology of thyroid neoplasms
The Bethesda system of reporting thyroid cytology is being currently adopted worldwide. Rapid advances have been made in the understanding of the genetics of thyroid cancers. Common genetic mutations include RAS, BRAF, p53, B Catenin, and PAX8/PPARγ
JB Thapa
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Update on pathology of retinoblastoma [PDF]
Retinoblastoma is caused by mutational inactivation of both alleles of the RB1 gene, which maps to chromosome 13q14 and encodes retinoblastoma protein that acts as a tumor suppressor.
Lata Singh, Seema Kashyap
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Application of molecular pathology in endocrine pathology [PDF]
Rapid growth in knowledge of cell and molecular biology led to the increased usage of molecular techniques in anatomical pathology. This is also due to the advances achieved in the techniques introduced in the last few years which are less laborious as compared to the techniques used at the beginning of the "molecular era". The initial assays were also
Ebru Serinsoz, Linke, Gaye Güler, Tezel
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Clinical proteomics and molecular pathology
Genomic and proteomic research is launching the next era of cancer molecular medicine. Molecular expression profiles can uncover clues to functionally important molecules in the development of human disease and generate information to subclassify human ...
Weidong Zhou +13 more
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