Results 71 to 80 of about 592,571 (263)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Multiple organ failure in the newborn: the point of view of the pathologist

Journal of Pediatric and Neonatal Individualized Medicine, 2014
One of the most severe events occurring in critically ill patients admitted to a neonatal intensive care unit (NICU) center is represented by the multiple organ failure (MOF), a systemic inflammatory response leading to a progressive organ dysfunction ...
Clara Gerosa, Eleonora Obinu, Daniela Fanni, Rossano Ambu, Gavino Faa   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Emergency surgical pathology in pregnant women and women in labor: analysis of the structure of morbidity and routing paths in St. Petersburg

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова
Relevance. Today, despite the development of medical technologies and the improvement of the logistical aspects of healthcare, the problem of unified treatment, diagnostic and routing algorithms for pregnant women and women in labor with urgent surgical ...
D. N. Popov, А. Yu. Korolkov, V. F. Bezhenar, L. А. Logvin, S. F. Bagnenko   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

p53 suppresses type II endometrial carcinomas in mice and governs endometrial tumour aggressiveness in humans

EMBO Molecular Medicine, 2012
Type II endometrial carcinomas are a highly aggressive group of tumour subtypes that are frequently associated with inactivation of the TP53 tumour suppressor gene.
Peter J. Wild, Kristian Ikenberg, Thomas J. Fuchs, Markus Rechsteiner, Strahil Georgiev, Niklaus Fankhauser, Aurelia Noske, Matthias Roessle, Rosmarie Caduff, Athanassios Dellas, Daniel Fink, Holger Moch, Wilhelm Krek, Ian J. Frew   +13 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Surgical pathology of Hirschsprung disease (HSCR)

World Journal of Pediatric Surgery
The practice, art and science of surgical pathology for disease entities evolves continuously. Standards for diagnosis and management of Hirschsprung disease (HSCR), variants and related dysmotility disorders are no exception. Morphologic parameters that
Raquel González, Hector L Monforte, Michael Wilsey   +2 more
doaj   +1 more source

Stem progenitor cells in the human pancreas

Journal of Pediatric and Neonatal Individualized Medicine, 2016
Early pancreas development, given its complexity, is generally considered as a paradigm for branching morphogenesis and for the development of two organs in one: the Langherans islets, programmed to secrete hormones into the bloodstream, and the exocrine
Giorgia Locci, Anna Paola Pinna, Angelica Dessì, Eleonora Obinu, Clara Gerosa, Maria Antonietta Marcialis, Maria Cristina Pintus, Marco Angiolucci, Vassilios Fanos, Rossano Ambu, Gavino Faa   +10 more
doaj   +1 more source