Results 181 to 190 of about 1,006,539 (210)

Expert consensus on clinical trial design guidelines for FLASH radiotherapy

open access: yesPrecision Radiation Oncology, EarlyView.
• FLASH radiotherapy has emerged as a transformative technology due to the underlying FLASH effect. • As FLASH radiotherapy moves toward clinical application, establishing standardized trial design principles is critical. • This expert consensus provides a roadmap for rigorous clinical evaluation of FLASH radiotherapy, accelerating safe translation of ...
Hui Luo   +9 more
wiley   +1 more source

Primary BPH Stromal Cell Cultures Exhibit Heightened Androgen‐Responsiveness

open access: yesThe Prostate, EarlyView.
ABSTRACT Background Benign prostatic hyperplasia (BPH) is the most common disease in aging males. BPH growth is androgen‐dependent, and it appears that androgens preferentially stimulate the growth of BPH as compared to normal prostate. The mechanism of preferential androgen stimulation of BPH growth is not clear.
Wei Chen   +9 more
wiley   +1 more source

Abstracts: Pathology Informatics 2015

open access: yesJournal of Pathology Informatics, 2015
doaj  

Schisandrin C Targets PPARγ to Induce Ferroptosis in Colorectal Cancer Cells and Promote M1 Macrophage Polarization

open access: yesPhytotherapy Research, EarlyView.
Schisandrin C: A Dual Anti‐Colorectal Cancer Strategy Targeting PPARγ. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer mortality, necessitating novel therapeutic strategies. Schisandrin C (SinC), a bioactive lignan from Schisandra chinensis, exhibits diverse pharmacological activities, but its anti‐CRC mechanisms are poorly ...
Xiao Wei   +4 more
wiley   +1 more source

Abstracts: Pathology Informatics 2014

open access: yesJournal of Pathology Informatics, 2014
doaj  

CT‐Based Biomarkers for Predicting Progressive Phenotypes in Interstitial Lung Diseases: A Retrospective Cohort Study

open access: yesRespirology, EarlyView.
This study demonstrates that the Single Time Point Prediction score, a novel machine learning–based imaging biomarker, along with established quantitative CT measures, is significantly associated with disease progression in non‐IPF ILD. This imaging metric may enable earlier identification of high‐risk patients and support personalised treatment ...
Ju Hyun Oh   +11 more
wiley   +1 more source

Pathology Informatics Summit 2017

open access: yesJournal of Pathology Informatics, 2017
doaj  

Responsive nanoheterojunctions for built‐in electric field‐promoted cascade tumor targeting and cuproptosis‐based therapy

open access: yesResponsive Materials, EarlyView.
Nanoheterojunctions have been synthesized as responsive biomaterials for cascade targeting of tumor cells and mitochondria, ROS‐mediated apoptosis and Cu‐promoted cuproptosis. And drug‐device‐field integration as an advanced paradigm of tumor treatment was employed for photo‐triggered tumor cell elimination in vitro and lesion eradication in vivo ...
Zhe Liu   +3 more
wiley   +1 more source

Ultrasensitive MicroRNA Detection Combining Reduced Graphene Oxide Electrolyte‐Gated Transistors and Machine Learning

open access: yesSmall, EarlyView.
We developed an ultrasensitive and highly selective biosensor by integrating bio‐functionalized reduced graphene oxide (rGO) electrolyte‐gated transistors (EGTs) and machine learning (ML) to detect miRNAs (miR‐34a, miR‐34b, and miR‐34c) associated with cancer and neurological disorders.
Ana Vitória Ferreira Deleigo   +7 more
wiley   +1 more source

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