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The integration of the adverse outcome pathway framework to radiation risk assessment

International Journal of Radiation Biology, 2020
A large body of radiobiological data has been generated over the past century using in vitro, animal and epidemiological models. This information represents global efforts to understand the mechanistic basis of radiation-induced health effects. However, it has been difficult to effectively integrate this data to derive meaningful information for ...
Vinita Chauhan   +2 more
openaire   +2 more sources

A transfer pathway modeling template for radiological environmental risk assessment

Stochastic Environmental Research and Risk Assessment, 2010
As radioactive human doses are calculated through food chain and exposure pathways, it is important to take a pathway analysis to determine all pathway contributions for further radiological environmental risk assessment. A challenge of contaminant fate and environmental pathway analysis is to handle a large number of environmental components and to ...
Jige Shen   +3 more
openaire   +1 more source

Risk Assessment and Early Mobilization Pathway Following Pediatric Tracheostomy: A Pilot Study

The Laryngoscope, 2020
Objectives/HypothesisTo confirm the standard of care pertaining to postoperative mobilization practices following initial tracheostomy, to establish face validity of novel early mobilization tools, and to conduct a safety and feasibility pilot study.Study DesignMulti‐institutional survey and prospective cohort study.MethodsExperts at our tertiary‐care ...
Pedrom C. Sioshansi   +4 more
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Making assessments while taking repeated risks: A pattern of multiple response pathways.

Journal of Experimental Psychology: General, 2014
Beyond simply a decision process, repeated risky decisions also require a number of cognitive processes including learning, search and exploration, and attention. In this article, we examine how multiple response pathways develop over repeated risky decisions.
Timothy J, Pleskac, Avishai, Wershbale
openaire   +2 more sources

Alien vertebrate risk assessment and invasion pathway modelling

2018
Alien species are a key driver of the ongoing biodiversity crisis. Changing patterns in the number and identity of transported alien species, and recent changes in the importance of different pathways for transporting alien species (e.g., recent decline in the role of acclimatisation societies vs.
openaire   +2 more sources

Multi-pathway assessment of human health risk posed by polycyclic aromatic hydrocarbons

Environmental Geochemistry and Health, 2015
To assess aggregate exposure to polycyclic aromatic hydrocarbons (PAHs) via several environmental media and pathways, a probabilistic framework for multi-pathway health risk assessment that integrates PAHs potency equivalence factors, risk estimation modeling, and Monte Carlo simulation was applied to a case study in Nanjing, which is an important ...
Changsheng, Qu   +4 more
openaire   +2 more sources

Applying the skin sensitisation adverse outcome pathway (AOP) to quantitative risk assessment

Toxicology in Vitro, 2014
As documented in the recent OECD report 'the adverse outcome pathway for skin sensitisation initiated by covalent binding to proteins' (OECD, 2012), the chemical and biological events driving the induction of human skin sensitisation have been investigated for many years and are now well understood.
Gavin, Maxwell   +13 more
openaire   +2 more sources

An Improved Environmental Pathway Model for Assessing High-level Waste Repository Risks

Health Physics, 1987
An environmental pathway model useful for assessing the postclosure radiological risks from high-level waste repositories has been developed. The model describes more fully than its predecessors the long-term build-up of radionuclides in the biosphere and is consequently better suited to the analysis of the prolonged radionuclide releases potentially ...
C M, Malbrain, R K, Lester
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Exploratory scenario analysis for disaster risk reduction: Considering alternative pathways in disaster risk assessment

International Journal of Disaster Risk Reduction, 2019
Abstract Disaster risk is a combination of natural hazards, along with society's exposure and vulnerability to them. Therefore, to ensure effective, long-term disaster risk reduction we must consider the dynamics of each of these components and how they change over extended periods due to population, economic and climatic drivers, as well as policy ...
Riddell, G.A.   +3 more
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Vertebral fracture assessment scans enhance targeting of investigations and treatment within a fracture risk assessment pathway

Osteoporosis International, 2013
Vertebral fracture assessment (VFA) scanning is a useful tool to aid vertebral fracture identification. In this evaluation, we show that introduction of a comprehensive fracture risk assessment pathway incorporating VFA has enhanced diagnosis of vertebral fractures and improved targeting of investigations and treatment.Vertebral fractures are a common ...
K-P, Kuet, D, Charlesworth, N F A, Peel
openaire   +2 more sources

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