Results 131 to 140 of about 10,730,120 (241)

of Checklist to operationalize measurement characteristics of patient-reported outcome measures

, 2016
of Checklist to operationalize measurement characteristics of patient-reported outcome ...
Melissa McPheeters (3548519), Irene Feurer (3548516), David Francis (39274), David Penson (3547055), Meaghan Noud (3548522)   +4 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Iterative qualitative approach to establishing content validation of a patient-reported outcome measure for arm lymphedema: the LYMPH-Q Upper Extremity Module

Journal of Patient-Reported Outcomes
Background Breast cancer-related lymphedema (BRCL) is one of the most common causes of upper extremity (UE) lymphedema in developed nations and substantially impacts health-related quality of life.
Manraj N. Kaur, Sylvie D. Cornacchi, Elena Tsangaris, Lotte Poulsen, Louise M. Beelen, Louise Bordeleau, Toni Zhong, Mads Gustaf Jorgensen, Jens Ahm Sorensen, Babak Mehrara, Joseph Dayan, Andrea L. Pusic, Anne F. Klassen   +12 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Translation and Cross-Cultural Adaptation into French of the Harris Hip Score and the Modified Harris Hip Score

Patient Related Outcome Measures
Hugo Bothorel,1 Anthony Pernoud,1 Panayiotis Christofilopoulos2 1Research Department, la Tour Hospital, Geneva, Switzerland; 2Department of Orthopaedics and Trauma Surgery, La Tour Hospital, Geneva, SwitzerlandCorrespondence: Anthony Pernoud, Tel +41 22 ...
Bothorel H, Pernoud A, Christofilopoulos P   +2 more
doaj  

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Development of a PROM set for patients with Guillain–Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP): study protocol

Health and Quality of Life Outcomes
Background Guillain–Barré syndrome (GBS) and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) are rare immune-mediated disorders of the peripheral nervous system. They cause significant physical and mental symptoms and functional impairments that
Farah Pelouto, Juanita. A. Haagsma, Bart C. Jacobs, Caroline B. Terwee   +3 more
doaj   +1 more source

Modification of an existing patient-reported outcome measure (PROM) for a new context of use in a seasonal infectious disease

, 2020
Modification of an existing patient-reported outcome measure (PROM) for a new context of use in a seasonal infectious ...
Carla DeMuro (4873858), Richard Osborne (13303218), Sandy Lewis (4873849), Todd Saretsky (13303239), Josephine Norquist (13303242), Matthew Phillips (352053), Lyn Finelli (251769), Emily Martin (278012)   +7 more
core