Results 141 to 150 of about 2,463,634 (361)

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Trends in shoulder surgery patient-reported outcome measures

JSES International, 2023
Patient-reported outcome measures (PROMs) are a vital part of the toolkit for the current practice of orthopedic surgery. We are witnessing the expansion of the use of PROMs in clinical practice and in research; the ultimate direction of this expansion ...
Rajpal Narulla, MBBS, MS, Mark Song, MBBS, MS, Sascha Karunaratne, BHlthSci(Hon)/MPhty, Christopher Smithers, MBBS, FRACS, FAOrthA, Jeffrey Petchell, MBBS, MMed (Clin Epi), FRACS, FAOrthA   +4 more
doaj  

Transportability of Outcome Measurement Error Correction: from Validation Studies to Intervention Trials [PDF]

arXiv, 2019
Many lifestyle intervention trials depend on collecting self-reported outcomes, like dietary intake, to assess the intervention's effectiveness. Self-reported outcome measures are subject to measurement error, which could impact treatment effect estimation.
arxiv  

Systematic review of the psychometric properties of patient-reported outcome measures for foot and ankle in rheumatoid arthritis [PDF]

, 2019
Background Foot problems and pain are common in patients with rheumatoid arthritis. Patient-reported outcome measures provide a standardized method of capturing patients’ perspectives of their functional status and wellbeing.
Cervera Garvi, Pablo, Gijón-Noguerón, Gabriel, Nester, Christopher J., Ortega-Avila, Ana Belen, Ramos Petersen, Laura   +4 more
core  

Systematic review of patient-reported outcome measures in patients with varicose veins. [PDF]

, 2017
BACKGROUND: Varicose veins can affect quality of life. Patient-reported outcome measures (PROMs) provide a direct report from the patient about the impact of the disease without interpretation from clinicians or anyone else.
Beebe-Dimmer, Brazier, Chen, Department of Health, Deyo, Digital, Evans, Fayers, Fitzpatrick, Food and Drug Administration, Francis, Garratt, Garratt, Garratt, Garratt, Guyatt, Guyatt, Kline, Lamping, Lattimer, Lattimer, Liberati, Maurins, McKenna, Michaels, Michaels, Mokkink, Morris, National Clinical Guideline Centre, Nijsten, Nunnally, Patrick, Paty, Poku, Shepherd, Terwee, What quality of life? The WHOQOL Group, Wright, Zimmerman   +38 more
core   +2 more sources

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Pedi-IKDC or KOOS-child: which questionnaire should be used in children with knee disorders?

BMC Musculoskeletal Disorders, 2019
Background The Pedi International Knee Documentation Committee (IKDC) and Knee Injury and Osteoarthritis Outcome Score (KOOS) child are validated questionnaires for children with knee disorders. The aim of this study was to translate these questionnaires
Charlotte A. van der Velden, M. C. van der Steen, Jens Leenders, Florens Q. M. P. van Douveren, Rob P. A. Janssen, Max Reijman   +5 more
doaj   +1 more source

From Patient Reported Outcome Measures to individualized prostate cancer care [PDF]

Prostate cancer (PCa) is the most common cancer among men in the Netherlands. Robot Assisted Radical Prostatectomy (RARP) for localized/locally advanced PCa is one of treatment options.
Tillier, Corinne Nathalie
core   +1 more source