Results 161 to 170 of about 2,463,634 (361)

The role of patient-reported outcome measures in the continuum of cancer clinical care: ESMO Clinical Practice Guideline.

Annals of Oncology, 2022
M. Di Maio, E. Basch, F. Denis, L. Fallowfield, P. Ganz, D. Howell, C. Kowalski, F. Perrone, A. Stover, Periasamy Sundaresan, L. Warrington, L. Zhang, K. Apostolidis, J. Freeman-Daily, C. Ripamonti, D. Santini   +15 more
semanticscholar   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Role of Patient-Reported Outcome Measures on Predicting Outcome of Bunion Surgery

, 2020
Background: Prior studies have suggested preoperative patient-reported outcome scores could predict patients who would achieve a clinically meaningful improvement with hallux valgus surgery. Our goal was to determine bunionectomyspecific thresholds using
Baumhauer, Judith F., Houck, Jeff, MacDonald, Ashlee   +2 more
core  

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Extracting Scalar Measures from Curves [PDF]

arXiv
The ability to order outcomes is necessary to make comparisons which is complicated when there is no natural ordering on the space of outcomes, as in the case of functional outcomes. This paper examines methods for extracting a scalar summary from functional or longitudinal outcomes based on an average rate of change which can be used to compare curves.
arxiv  

Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidance [PDF]

, 2006

openalex   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Educating patients about patient-reported outcomes—are we there yet?

Journal of Patient-Reported Outcomes
Background Using Patient Reported Outcome Measures (PROMs) in clinical settings can improve patient outcomes by enhancing communication between patient and provider.
Elizabeth Unni, Maud M. van Muilekom, Kate Absolom, Bishnu Bajgain, Lotte Haverman, Maria Santana   +5 more
doaj   +1 more source

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source

Patient-driven research priorities for patient-centered measurement

BMC Health Services Research
Background Patient-centred measurement (PCM) emphasizes a holistic approach wherein the voices of patients are reflected in the standardized use of patient-reported outcome and experience measures and are represented throughout the continuum of ...
A. Fuchsia Howard, Linda Warner, Lena Cuthbertson, Richard Sawatzky   +3 more
doaj   +1 more source