Results 211 to 220 of about 3,046,490 (341)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Correction: A multicomponent, high-intensity, patient-centered care intervention to optimize transitional care coordination for complex multimorbid people: a pre-post design. [PDF]

Front Med (Lausanne)
Del Pino-Sedeño T, González de León B, García Hernández M, Coronil Olmedo P, Reyes Melián YS, Martínez Hernández V, García Bautista E, Barrios Arraez E, Barreto Cruz S, Abrante-Luis A, García-Bello MA, González-Hernández Y, López-Rodríguez JA, Vázquez-Díaz JR.   +13 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Achieving patient centered care: Communication and cultural competence

Indian Journal of Endocrinology and Metabolism, 2013
Jaikrit Bhutani, Sukriti Bhutani, Jai Kumar   +2 more
doaj   +1 more source

Polypharmacy and deprescribing attitudes among stroke survivors: Opportunities for enhanced patient centered care. [PDF]

J Stroke Cerebrovasc Dis
Chao AK, Burke JF, Bi R, Lin CC, Skolarus LE.   +4 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Exploring patient-centered care delivery in outpatient settings for older adults: a scoping review and recommendations for implementation in countries with low and middle income. [PDF]

BMC Geriatr
Hatam N, Askarian M, Taherifard E, Ahmadkhani A, Golabi F, Bordbar S, Taherifard E.   +6 more
europepmc   +1 more source

Evaluation of severe adverse cutaneous drug reactions in patients admitted to tertiary care center: A cross‐sectional study [PDF]

Mohammad Amin Moshayedi, Ali Asilian, Fatemeh Mokhtari   +2 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Editorial: Promoting patient-centered care for pediatric rheumatology across Africa. [PDF]

Front Pediatr
Hamdi W, Migowa A.
europepmc   +1 more source