Results 131 to 140 of about 1,790,302 (324)

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Patient-centred care in general dental practice--a systematic review of the literature. [PDF]

, 2016
Journal ArticleResearch Support, Non-U.S. Gov'tReviewBACKGROUND: Delivering improvements in quality is a key objective within most healthcare systems, and a view which has been widely embraced within the NHS in the United Kingdom. Within the NHS, quality
Cooper, Chris, Frost, J, Kay, E, Mills, I, Moles, DR   +4 more
core   +1 more source

Protocol for the development and validation procedure of the managing the link and strengthening transition from child to adult mental health care (MILESTONE) suite of measures [PDF]

, 2020
Background: Mental health disorders in the child and adolescent population are a pressing public health concern. Despite the high prevalence of psychopathology in this vulnerable population, the transition from Child and Adolescent Mental Health ...
Adams, L., Davidović, N., de Girolamo, G., Dieleman, G. C., Fiori, F., for the MILESTONE Consortium, Franić, T., Heaney, N., Lievesley, K., Madan, J., Maras, A., Mastroianni, M., McNicholas, F., Paul, M., Purper-Ouakil, D., Sagar-Ouriaghli, I., Santosh, P., Schulze, U., Signorini, G., Singh, J., Singh, S. P., Street, C., Tah, P., Tremmery, S., Tuomainen, H., Verhulst, F. C., Warwick, J., Wolke, D.   +27 more
core   +6 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Developing a patient-centered outcome measure for complementary and alternative medicine therapies II: Refining content validity through cognitive interviews [PDF]

, 2011
BACKGROUND: Available measures of patient-reported outcomes for complementary and alternative medicine (CAM) inadequately capture the range of patient-reported treatment effects.
Allison L Hopkins, Cheryl Ritenbaugh, Colette M Sims, Jennifer J Thompson, Kimberly L Kelly, Stephen J Coons   +5 more
core   +1 more source

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Reliability and validity of an Ambulance Patient Reported Experience Measure (A-PREM): pilot study [PDF]

, 2017
Background There are no prehospital ambulance Patient Reported Experience Measures (A-PREMs) routinely used to support service comparisons and improvement.
Akanuwe, Joseph, Siriwardena, Niro, Spaight, A., Togher, Fiona   +3 more
core   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

The Utility of Outcome Studies in Plastic Surgery [PDF]

, 2014
Summary: Outcome studies help provide the evidence-based science rationalizing treatment end results that factor the experience of patients and the impact on society.
Chung, Kevin C., Dionisopoulos, Tassos, Ibrahim, Ahmed M. S., Lin, Samuel J., Sinno, Hani, Slavin, Sumner A.   +5 more
core   +2 more sources

Deriving and validating a brief measure of treatment burden to assess person-centered healthcare quality in primary care: a multi-method study

BMC Family Practice, 2020
Background In primary care there is a need for more quality measures of person-centered outcomes, especially ones applicable to patients with multiple chronic conditions (MCCs). The aim of this study was to derive and validate a short-form version of the
David T. Eton, Mark Linzer, Deborah H. Boehm, Catherine E. Vanderboom, Elizabeth A. Rogers, Marlene H. Frost, Mike Wambua, Miamoua Vang, Sara Poplau, Minji K. Lee, Roger T. Anderson   +10 more
doaj   +1 more source