Results 111 to 120 of about 2,966,345 (343)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Physical therapy management, surgical treatment, and patient-reported outcomes measures in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome [PDF]

, 2019
OBJECTIVE: To assess the results of physical therapy management and surgical treatment in a prospective observational cohort of patients with neurogenic thoracic outlet syndrome (NTOS) using patient-reported outcomes measures. METHODS: Of 183 new patient
Abuirqeba, Ahmmad A, Balderman, Joshua, Bottros, Michael M, Earley, Jeanne A, Eichaker, Lindsay, Jayarajan, Senthil N, Pate, Cassandra, Thompson, Robert W   +7 more
core   +1 more source

Circadian rest-activity rhythm as an objective biomarker of patient-reported outcomes in patients with advanced cancer [PDF]

, 2018
Background Psychosocial symptoms often cluster together, are refractory to treatment, and impair health‐related quality of life (HR‐QoL) in cancer patients.
Ballesta, Annabelle, Bjarnason, Georg A., Bouchahda, Mohamed, Dallmann, Robert, Giacchetti , Syvie, Haydar, Mazen, Innominato, Pasquale F., Karaboué, Abdoulaye, Komarzynski, Sandra, Lévi, Francis A., Palesh, Oxana G., Spiegel, David, Ulusakarya , Ayhan, Wreglesworth, Nicholas I.   +13 more
core   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Ruptured intracranial aneurysms: the overall effect of treatment and the influence of patient selection and data presentation on the reported outcome. [PDF]

, 1985
R. S. Maurice‐Williams, Henry Marsh
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Current state of quality of life and patient-reported outcomes research [PDF]

, 2019
The 5th EORTC Quality of Life in Cancer Clinical Trials Conference presented the current state of quality of life and other patient-reported outcomes (PROs) research from the perspectives of researchers, regulators, industry representatives, patients and
5th EORTC Quality Life Canc, Apostolidis, K., Bottomley, A., Calvert, M., Campbell, A., Coens, C., Darlington, A.S., Dueck, A.C., Fallowfield, D.L., Flechtner, H., Ganz, P.A., Gotay, C., Greimel, E., Gronvold, M., Holzner, B., Kluetz, P.G., Koller, M., Kulis, D., Lewis, I., Martinelli, F., Musoro, J.Z., O'Connor, D., Oliver, K., Pe, M., Poll-Franse, L. van de, Reijneveld, J.C., Ringash, J., Sasseville, M., Schunemann, H., Snyder, C., Stephens, R., Tafuri, G., Taphoorn, M.J.B., Tomaszewski, K.A., Velikova, G., Wheelwright, S., Wilson, R.   +36 more
core   +5 more sources

Development of a quality of life measure for left ventricular assist device recipients using a mixed methods approach

ESC Heart Failure
Background Left ventricular assist device (LVAD) recipients report symptom improvement but find adjusting to life with the LVAD challenging. These challenges are unique, and existing patient‐reported outcome measures (PROMs) do not reflect their ...
Anita L. Slade, Christel McMullan, M. Sayeed Haque, Stephen Griffith, Laura Marley, David Quinn, Margaret E. O'Hara, Mike Horton, Melanie J. Calvert, Hoong Sern Lim, Deirdre A. Lane   +10 more
doaj   +1 more source

On-line Medical Command and Patient-Initiated Refusals of Prehospital Care: Patient Outcome and Ambulance Call Report Documentation [PDF]

, 1993
David C. Cone, D.T Kim, S.J. Davidson
openalex   +1 more source