Results 111 to 120 of about 2,568,476 (309)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Developing a real-time electronic symptom monitoring system for patients after discharge following cancer-related surgery

BMC Cancer, 2019
Background Patients undergoing major cancer surgery frequently require post-acute care for complications and adverse effects. Enhanced recovery after surgery programmes mean that patients are increasingly discharged home earlier.
Kerry N. L. Avery, Hollie S. Richards, Amanda Portal, Trudy Reed, Ruth Harding, Robert Carter, Leon Bamforth, Kate Absolom, Elaine O’Connell Francischetto, Galina Velikova, Jane M. Blazeby   +10 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

State of the psychometric methods: patient-reported outcome measure development and refinement using item response theory.

, 2019
BACKGROUND:This paper is part of a series comparing different psychometric approaches to evaluate patient-reported outcome (PRO) measures using the same items and dataset.
Langer, Michelle M, Reeve, Bryce B, Stover, Angela M, Chen, Wen-Hung, McLeod, Lori D   +4 more
core   +1 more source

Is patient-centredness in European hospitals related to existing quality improvement strategies? Analysis of a cross-sectional survey (MARQuIS study). [PDF]

, 2009
BACKGROUND: There is growing recognition of patients' contributions to setting objectives for their own care, improving health outcomes and evaluating care.
Lombarts, MJMH, Klazinga, N., Groene, O., Groene, O, Thompson, A, Lombarts, M.J.M.H., Lombarts, M. J. M. H., Klazinga, N, Suñol, R, Suñol, R., Groene, Oliver, Suñol Sala, Rosa, Alonso, J., Alonso, J, Thompson, A.   +14 more
core   +1 more source

Examining the face validity of the EQ-HWB-9 in dementia: caregiver interpretation across “Today” and “7-Day” recall periods

Health and Quality of Life Outcomes
Background This study aimed to assess the face validity of the EQ Health and Wellbeing 9 (EQ-HWB-9) for use as a proxy by informal caregivers of community-dwelling people living with dementia (PlwD).
Maresa Buchholz, Lidia Engel, Feng Xie, Bernhard Michalowsky   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The development and validation of a patient-reported outcome measure of health-related quality of life for patients with pressure ulcers: PUQOL Project [PDF]

, 2011
This thesis aimed to establish the impact of pressure ulcers (PUs) on health-related quality of life (HRQL) and determine the need for a PU-specific patient-reported outcome (PRO) instrument.
Gorecki, Claudia Anna
core  

Strategies to use tablet computers for collection of electronic patient-reported outcomes

, 2015
Background Mobile devices are increasingly being used for data collection in research. However, many researchers do not have experience in collecting data electronically.
Schick-Makaroff, Kara, Molzahn, Anita
core   +1 more source