Results 71 to 80 of about 1,594,407 (306)

The simulation of action disorganisation in complex activities of daily living [PDF]

, 2005
Action selection in everyday goal-directed tasks of moderate complexity is known to be subject to breakdown following extensive frontal brain injury. A model of action selection in such tasks is presented and used to explore three hypotheses concerning ...
Anderson JR, Cooper RP, Cooper RP, Duncan J, Fuster JM, Grafman J, Houghton G, Houghton G, Humphreys GW, Humphreys GW, Liepmann H, Luria AR, McClelland JL, Myrna F. Schwartz, Norman DA, Norman DA, Passingham RE, Peter Yule, Pick A, Poeck K, Reason JT, Reason JT, Richard P. Cooper, Rumiati RI, Schwartz MF, Shallice T, Sirigu A, Tim Shallice, Verfaellie M, Williams RJ, Yule P, Zipf GK   +31 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Life history strategy and romantic satisfaction in patients’ behavior

Frontiers in Psychology
According to evolutionary psychologists, an individual—consciously or not—who allocates resources for somatic effort focuses on homeostasis and the protection of themselves and others.
Cristina Ene, Vlad Burtaverde, Peter Karl Jonason, Peter Karl Jonason, Felix Brehar, Viorel Pruna   +5 more
doaj   +1 more source

Apoptotic epitope-specific CD8+ T cells and interferon signaling intersect in chronic hepatitis C virus infection [PDF]

, 2015
CD8(+) T cells specific to caspase-cleaved antigens derived from apoptotic T cells represent a principal player in chronic immune activation (CIA). Here, we found that both apoptotic epitope (AE)-specific and hepatitis C virus (HCV)-specific CD8(+) T ...
Accapezzato, Daniele, Barnaba, Vincenzo, Calvo, Ludovica, Cavallari, EUGENIO NELSON, Citro, Alessandra, Coccia, Eliana M, D'Ettorre, Gabriella, DE MARZIO, Paolo, DI FILIPPO, Simona, Grazi, Gian Luca, Labbadia, Giancarlo, Martini, Helene, Martire, Carmela, Piconese, Silvia, Rizzo, Fabiana, Sette, Alessandro, Severa, Martina, Sidney, John, Vullo, Vincenzo   +18 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Determinants of activation for self-management in patients with COPD

International Journal of COPD, 2016
YJG Korpershoek,1–3 ID Bos-Touwen,2 JM de Man-van Ginkel,2,4 J-WJ Lammers,3 MJ Schuurmans,1,2 JCA Trappenburg2 1Research Group Chronic Illnesses, Faculty of Health Care, University of Applied Sciences Utrecht, 2Department of Rehabilitation ...
Korpershoek YJG, Bos-Touwen ID, de Man-van Ginkel JM, Lammers JWJ, Schuurmans MJ, Trappenburg JCA   +5 more
doaj  

I am ready to see you now, Doctor! A mixed‐method study of the Let's Discuss Health website implementation in Primary Care

Health Expectations, 2021
Background Let's Discuss Health (LDH) is a website that encourages patients to prepare their health‐care encounters by providing communication training, review of topics and questions that are important to them.
Marie‐Thérèse Lussier, Claude Richard, Fatoumata Binta Diallo, Nathalie Boivin, Catherine Hudon, Élie Boustani, Holly Witteman, Jalila Jbilou   +7 more
doaj   +1 more source

A novel streamlined trauma response team training improves imaging efficiency for pediatric blunt abdominal trauma patients [PDF]

, 2019
Background/purpose The morbidity and mortality of children with traumatic injuries are directly related to the time to definitive management of their injuries.
Cross, Keith, Fallat, Mary E., Laniewicz, Megan, Nti, Benjamin K., Rominger, Annie, Skaggs, Tracy   +5 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Patient activation for self-management is associated with health status in patients with atrial fibrillation

Patient Preference and Adherence, 2018
Pamela J McCabe,1 Lynette G Stuart-Mullen,1 Christopher J McLeod,2 Thomas O Byrne,3 Monika M Schmidt,2 Megan E Branda,3 Joan M Griffin3,4 1Mayo Clinic Department of Nursing, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN, USA ...
McCabe PJ, Stuart-Mullen LG, McLeod CJ, O Byrne T, Schmidt MM, Branda ME, Griffin JM   +6 more
doaj