Tobramycin pharmacokinetic and pharmacodynamic targets in people with cystic fibrosis
Intravenous tobramycin is a first‐line treatment for Pseudomonas aeruginosa infection in people with cystic fibrosis (CF). Tobramycin exhibits concentration‐dependent activity; however, excess drug exposure can lead to nephrotoxicity and ototoxicity. While dosing typically targets serum peak (Cmax) and trough (Cmin) concentrations, the area under the ...
Kiera H. Harwood +6 more
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Triple M Syndrome Associated With Concurrent Durvalumab and Olaparib Therapy in Metastatic Cholangiocarcinoma: A Case Report. [PDF]
Nilsen O +6 more
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Protocol for the INterstitial lung Disease EXacerbations (INDEX) Study: a retrospective multicentre cohort study. [PDF]
Goodwin AT +11 more
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Randomised, double-blind clinical trial protocol to evaluate whether early and perioperative tranexamic acid administration reduces transfusion rates and blood loss of patients undergoing hip fracture surgery in Spain. [PDF]
Arrieta J +4 more
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Heparin-binding protein and Endothelin-1 in critical COVID-19. [PDF]
Halldorsdottir H +6 more
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A Single-Centre Review of Outcomes of Delayed Admission to a Burns Unit. [PDF]
Isaacs Q +3 more
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Evaluating Modified Early Warning Score Compliance to Minimize Unnecessary Intensive Care Unit Admissions: A Descriptive Cross-Sectional Needs Assessment at a University Teaching Tertiary Care Centre to Inform Quality Improvement Implementation. [PDF]
Khalil M +15 more
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