Results 151 to 160 of about 19,606 (268)

Salvianolic Acid C Protects Against Hepatic Ischemia–Reperfusion Injury via Heat Shock Protein 90α‐Mediated Activation of the Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling Pathway

Phytotherapy Research, EarlyView.
Salvianolic acid C (SaC) protects against hepatic ischemia–reperfusion injury (HIRI) by upregulating HSP90α and activating the PI3K/AKT pathway, thereby alleviating oxidative stress, inflammation, apoptosis, and necrosis. ABSTRACT Hepatic ischemia–reperfusion injury (HIRI) is a major challenge in liver surgery, and effective pharmacological ...
Pingping Qiao, Alimu Tulahong, Xinlu Xu, Tiemin Jiang, Ruiqing Zhang, Yanze Lin, Zhongdian Yuan, Rexiati Ruze, Yingmei Shao   +8 more
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source

Empowering healing: The transformative role of patient and public involvement in preventing and healing wounds

Patient and public involvement (PPI) in healthcare is based on the principle that involving patients in aspects of planning, designing and conducting research can lead to improvements in the quality, and relevance of the research outcomes [1].
Wilson, H, Budri, A, Patton, D, O'Connor, T, Moore, Z   +4 more
core   +1 more source

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

Factors Associated With Hormone Replacement Therapy Use: A Systematic Review and Meta‐Analysis

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To identify factors associated with HRT uptake among women. Design A systematic review and meta‐analysis to identify factors associated with HRT uptake. Setting Retrospective and prospective cohort studies, case–control studies and cross‐sectional studies from any country and in any language. Population The study population was women
Wema Meranda Mtika, Deborah Allen, Eve Tranter, Grace Glover, Janice Hoang, Sarah Hillman, Carol Coupland, Julia Hippisley‐Cox, Lynn Tatnell, Jennifer A. Hirst   +9 more
wiley   +1 more source

The Impact of Heavy Menstrual Bleeding on Quality of Life: A Mixed‐Methods Survey Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To examine the physical, psychological, social, and functional impact of heavy menstrual bleeding (HMB) using a mixed‐methods approach. Design Mixed‐methods online survey. Population A UK‐wide sample of adults assigned female at birth with lived experience of HMB.
Michalina Drejza, Lily S. Nicholson, Gabrielle Paquette, Mehar Chawla, Claire L. Vale, Ewelina Rogozińska, Ngawai Moss, Niccola Hutchinson‐Pascal, Bassel H. Al Wattar   +8 more
wiley   +1 more source

Patient and Public Involvement (PPI) and the research process [PDF]

, 2018
openaire   +1 more source

Association Between Proton‐Pump Inhibitors and Muscle Strength in Older Adults: A Population‐Based Analysis

Journal of Digestive Diseases, EarlyView.
In this population‐based study of 616 older adults, we analyzed the associations of proton‐pump inhibitor (PPI) use with handgrip strength, 4‐m walking performance, and armchair push–pull performance. After adjusted for age, sex, body mass index, and comorbidity burden using the Charlson Comorbidity Index (CCI), only the association with armchair push ...
Jaakko Ollila, Konsta Teppo, Kimmo Salminen, Adriana Lääti, Jenni Vire, Matti Viitanen, Ville Langén   +6 more
wiley   +1 more source

Evaluating the Process and Outcome of a Primary Care Patient and Public Involvement (PPI) Programme: A Pilot Study. [PDF]

Health Expect
Oka P, Ng CJ, Salim H, Lee PY, Ong R, Tan NC.   +5 more
europepmc   +1 more source