EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect
Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu +10 more
wiley +1 more source
ABSTRACT Objectives Understudied populations such as those with intellectual disabilities (ID) face significant disease burden and oral health disparities. Systematic exclusion from oral health research contributes to resultant health inequalities, limits understanding of the determinants and implications of disease, and hinders the ability to improve ...
Katrina Byrne +4 more
wiley +1 more source
The Development of Principles for Patient and Public Involvement (PPI) in Preclinical Spinal Cord Research: A Modified Delphi Study. [PDF]
Carroll P +11 more
europepmc +1 more source
It’s important to define what your organisation means by PPI. It is helpful to view the different ways of involving people in research as a spectrum. Your strategy should make it clear that while participation of patients in research studies and the engagement of patients/the public through the imparting of information are very useful, they are ...
openaire +1 more source
Behaviour Support in Dentistry Core Outcomes (BeSiDe‐CO): A Core Outcome Set Development Study
ABSTRACT Objectives To develop a Core Outcome Set suitable for adults and children for use in studies of Dental Behaviour Support (DBS) techniques, including non‐pharmacological DBS, sedation and General Anaesthesia research. Methods Two systematic reviews generated a preliminary list of candidate outcomes that were shared with Key Stakeholders (KSG ...
Caoimhin Mac Giolla Phadraig +22 more
wiley +1 more source
Perspectives of researchers and clinicians on patient and public involvement (PPI) in preclinical spinal cord research: An interview study. [PDF]
Carroll P +10 more
europepmc +1 more source
Abstract Aim To explore the experiences of mental health difficulties and access to mental health support among young people with cerebral palsy (CP). Method We used a qualitative descriptive design. Participants were young people with CP aged 13 to 25 years and parents of children with CP (6–25 years).
Manjula Manikandan +15 more
wiley +1 more source
Understanding one health challenges in marginalized urban settings: A patient and public involvement (PPI) approach from the CHIP consortium activities across four global cities. [PDF]
Manikam L +15 more
europepmc +1 more source
Patient and public involvement (PPI) in UK surgical trials: a survey and focus groups with stakeholders to identify practices, views, and experiences. [PDF]
Crocker JC +12 more
europepmc +1 more source
School attendance in individuals with cerebral palsy in Brazil
This graphical abstract summarizes the main findings of the study. Abstract Aim To identify factors associated with school attendance among Brazilian children, adolescents, and young adults with cerebral palsy (CP) using population‐based data from the Brazilian Cerebral Palsy Register (BrCPR).
Ricardo Rodrigues de Sousa Junior +10 more
wiley +1 more source

