Results 71 to 80 of about 19,606 (268)

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

Stroke Prevention Rehabilitation Intervention Trial of Exercise (SPRITE) - a randomised feasibility study

BMC Cardiovascular Disorders, 2017
Background The value of cardiac rehabilitation (CR) after a transient ischaemic attack (TIA) or minor stroke is untested despite these conditions sharing similar pathology and risk factors to coronary heart disease.
Neil Heron, Frank Kee, Jonathan Mant, Philip M. Reilly, Margaret Cupples, Mark Tully, Michael Donnelly   +6 more
doaj   +1 more source

Practical guide: Patient and public involvement in antimicrobial medicines development research [PDF]

, 2018
Patient and public involvement (PPI) in antimicrobial medicines development research is new and unfamiliar. There are few established patient support groups or voluntary organisations in the field of infection sciences given the short-term nature of many
Kok, Michele, Grier, Sally, Evans, David, MacGowan, Alasdair, Gibson, Andy   +4 more
core  

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Key stakeholders’ views, experiences and expectations of patient and public involvement in healthcare professions’ education: a qualitative study

BMC Medical Education, 2022
Background Patients and the public have an integral role in educating healthcare professionals. Authentic partnerships between higher education institutions and patients and the public are essential.
Megan Cullen, Cathal Cadogan, Susmi George, Siobhan Murphy, Siobhan Freeney, Robbie Fitzpatrick, Judith Strawbridge   +6 more
doaj   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

‘Plugging the gap’: development of a plain language glossary for statistical methodology research

Research Involvement and Engagement
Background Plain language glossaries of research-related terms are a useful resource for Patient and Public Involvement and Engagement (PPIE) activities.
Sarah Booth, Molly Wells, Clareece Nevill, Lucy Teece, Barbara Czyznikowska, Gurpreet Grewal-Santini, Mary Mancini, Farheen Yameen, Suzanne C Freeman   +8 more
doaj   +1 more source

Experiences of pain and pain management in advanced disease and serious illness for people from South Asian communities in Leeds and Bradford: a qualitative interview study

BMC Palliative Care, 2023
Background Pain is a significant problem for many people with advanced disease or a serious illness. Culture and ethnicity can affect the experience and management of pain.
Gemma Clarke, Jodie Crooks, Michael I. Bennett, Zarina Mirza, Ruby Bhatti OBE, Wali Nazar, Rahila Mughal, Shenaz Ahmed   +7 more
doaj   +1 more source

The impact of Covid-19 pandemic on hospices: A systematic integrated review and synthesis of recommendations for policy and practice [version 2; peer review: 2 approved]

AMRC Open Research, 2023
Background: The Covid-19 pandemic resulted in the development of numerous recommendations for practice and policy for specialist palliative care provided by hospices in United Kingdom (UK), as hospices were significantly affected by the pandemic and ...
Helen Wesson, Shalene van Langen-Datta, Jeremy Dale, Joanna Fleming, Abi Eccles, John I. MacArtney, Catherine Grimley, Sarah Mitchell, Kathryn Almack, Catriona Mayland, Ruth Driscoll, Lesley Roberts, Lynn Tatnell   +12 more
doaj   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source