ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Improving Clinical Diagnostics and Patient Care through Artificial Intelligence and Biosensor Technologies. [PDF]
ACS OmegaBaluta S +4 more
europepmc +1 more source
Conflating Medical Care With Patient Care [PDF]
Journal of Graduate Medical Education, 2017 openaire +2 more sources
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Role Clarity Among Patient Care Technicians in Saudi Arabia: Outcomes of a Structured Educational Program. [PDF]
Healthcare (Basel)Alreshidi NM +10 more
europepmc +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
The relationships between neuropsychological screening instruments and nurses' observations of geriatric patients in a long-term care facility [PDF]
, 1997 Martin L. Rohling, Michelle Lam
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Duffy-null variant and practical implications for patient care: a scoping review. [PDF]
BMJ OpenAsiimwe E, Ngo TP, Ziv E, Leavitt AD.
europepmc +1 more source
"You can't ask questions about what you don't know". Determing the needs of patients with high grade gliomas and their carers [PDF]
, 2007 Georgia Halkett +3 more
openalex +1 more source