Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Healthcare services managers: what information do they need and use? [PDF]
, 2008 Objectives: To gain insight into the information behaviour of healthcare services managers as they draw on information while engaged in decision making unrelated to individual patient care.
Bath, P.A., Booth, A., MacDonald, J.
core +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The Business Case for Community Paramedicine: Lessons from Commonwealth Care Alliance's Pilot Program [PDF]
, 2016 Mobile integrated health care and community paramedicine (MIH-CP) programs expand the role of traditional emergency medical services personnel to address non-emergency needs and bring outpatient primary and urgent care into patients' homes.
Dominick Esposito +6 more
core
"Hope for the best, prepare for the worst": A qualitative interview study on parents' needs and fears in pediatric advance care planning. [PDF]
, 2016 Pediatric advance care planning is advocated by healthcare providers because it may increase the chance that patient and/or parent wishes are respected and thus improve end-of-life care.
Borasio, G.D. +4 more
core +2 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
How Has ‘What Matters to You’ Been Used for Patient Care? A Scoping Review
Health ExpectationsIntroduction Asking patients ‘What matters to you?’ (WMTY) was first introduced in 2012 as an approach to person‐centred care and has since been integrated into healthcare frameworks internationally.
Carrie Janerka +3 more
doaj +1 more source
A learning community approach to identifying interventions in health systems to reduce colorectal cancer screening disparities. [PDF]
, 2018 Although colorectal cancer (CRC) screening in the United States has been increasing, screening rates are not optimal, and there are persistent disparities in CRC screening and mortality, particularly among minority patients.
DiCarlo, Melissa +6 more
core +2 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
General practice palliative care: Patient and carer expectations, advance care plans and place of death-a systematic review [PDF]
, 2018 Background: With an increasing ageing population in most countries, the role of general practitioners (GPs) and general practice nurses (GPNs) in providing optimal end of life (EoL) care is increasingly important.
Aubin, Michele +11 more
core +2 more sources