Results 51 to 60 of about 537,684 (255)

A Readability Analysis of Online Cardiovascular Disease-Related Health Education Materials

Health Literacy Research and Practice, 2019
Background: Online cardiovascular health materials are easily accessible with an Internet connection, but the readability of its content may limit practical use by patients.
Varun Ayyaswami, Divya Padmanabhan, Manthan Patel, Arpan Vaikunth Prabhu, David R. Hansberry, Nitin Agarwal, Jared W. Magnani   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Bladder Cancer Health Literacy: Assessing Readability of Online Patient Education Materials

Bladder Cancer, 2021
BACKGROUND: Understanding of health-related materials, termed health literacy, affects decision makings and outcomes in the treatment of bladder cancer.
Lauren E. Powell, Theodore I. Cisu, Adam P. Klausner   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Understanding Health Literacy Through Patients' Interpretation of Health Education Leaflets: A Thematic Narrative Review

Health Expectations
Background Understanding how patients interpret health education leaflets is essential in promoting equitable and effective health communication. This narrative thematic review synthesises current evidence and introduces a conceptual model to inform ...
Yung‐Hui Tang, Chin Tsai Lin, Li‐Chu Wu   +2 more
doaj   +1 more source

Quality of Dietetic Patient Education Materials for Diabetes and Gastrointestinal Disorders: Where Can We Do Better?

Dietetics
(1) Background: Patient education materials are frequently used by dietitians to support counselling and reinforce key concepts. No studies have examined the quality of dietetic patient education materials for diabetes and common gastrointestinal ...
Kelly Lambert, Olivia Hodgson, Claudia Goodman   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

What should lung cancer patients know before surgery? A Delphi consensus studyCentral MessagePerspective

JTCVS Open
Objective: Preoperative patient education improves surgical outcomes but high variability of existing patient education materials (PEMs) exists. This study establishes thoracic surgeon consensus on essential content included in PEMs to help patients to ...
Woorin Jang, BS, Mark K. Ferguson, MD, Mara Antonoff, MD, Mark Block, MD, Malcolm DeCamp, Jr., MD, Elisabeth Dexter, MD, Jessica Donington, MD, MSCR, Melanie Edwards, MD, Crystal Erickson, MD, David Tyler Greenfield, MD, Eric L. Grogan, MD, MPH, Jeffrey Hagen, MD, Matthew L. Inra, MD, Jody Kaban, MD, Peter J. Kneuertz, MD, Sean Kwon, MD, Geoffrey Lam, MD, Keith Mortman, MD, Keith Naunheim, MD, Brian Pettiford, MD, Daniel P. Raymond, MD, Janani S. Reisenauer, MD, R. Taylor Ripley, MD, Lary Robinson, MD, Christopher W. Seder, MD, Harmik Soukiasian, MD, Ruchi Thanawala, MD, Nakul Valsangkar, MBBS, Nirmal Veeramachaneni, MD, Jason Wallen, MDCM, Thomas Watson, MD, Ory Wiesel, MD, Maria Lucia L. Madariaga, MD   +32 more
doaj   +1 more source