Results 171 to 180 of about 16,134,108 (309)

Validation of the Patient Health Questionnaire-2 (PHQ-2) in Detecting Depression Among Older Adults. [PDF]

Aging Med (Milton)
Salis F, Belfiori M, Ferrau A, Bernardini E, Concas E, Lugas AM, Mandas A.   +6 more
europepmc   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

The validity and reliability of the Patient Health Questionnaire - Adolescent version (PHQ - A) in Vietnam. [PDF]

BMC Psychol
Truong NA, Pityaratstian N, Lam TN, Do TT, Nguyen Thi HN, Tran AN, Nguyen TTS, Prasartpornsirichoke J.   +7 more
europepmc   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Adaptation to San Martín Quechua and psychometric analysis of the Patient Health Questionnaire (PHQ-9) in Peruvian adults. [PDF]

BMC Psychol
Cjuno J, Gomez-Hurtado H, Shupingahua-Jimenez C, Aranda-Turpo J, Julca Guerrero F, Velásquez-Castillo N, Anco EWA, Bazalar-Palacios J, Bazo-Alvarez JC.   +8 more
europepmc   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Investigating Patient Outcome Measures in Mental Health [PDF]

This report examines the feasibility of incorporating patient outcomes in mental health into a productivity measure. It examines which outcome measures are most commonly used in mental health, the practical issues about collecting these outcome measures,
Rowena Jacobs
core  

Psychometric properties of the Patient Health Questionnaire-9 and the Generalized Anxiety Disorder-7 in Mexican cancer patients. [PDF]

Palliat Support Care
Galindo-Vázquez O, Ruíz-García E, Álvarez-Gómez RM, Lerma Talamantes A, González Ling AM, Ramírez Orozco M, Espinoza Zamora R, Uriostegui Garduño AB, Núñez-Hernández JE, Espinoza Bello M, Costas-Muñiz R.   +10 more
europepmc   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Reliability and validity of the Kurdish version of the patient health questionnaire-15 in a trauma-affected population. [PDF]

BMC Psychiatry
Mohammed I, Sharif HA, Kizilhan J, Hasin B, Papiol S, Ruebekeil M, Heilbronner U, Schulze TG, Hautzinger M.   +8 more
europepmc   +1 more source