Results 101 to 110 of about 543,181 (304)

Implementation of Industrial Additive Manufacturing: Intelligent Implants and Drug Delivery Systems

open access: yesJournal of Functional Biomaterials, 2018
The purpose of this study is to demonstrate the ability of additive manufacturing, also known as 3D printing, to produce effective drug delivery devices and implants that are both identifiable, as well as traceable.
Jan Sher Akmal   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

SHORT NOTES RBF-Networks for Identification of

open access: yes, 2008
The response of the critically ill patient to the drugs necessary to sustain the vital physiological functions shows a strongly nonlinear dynamic behaviour.
Patient Pharmacokinetics
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Information security strategy in telemedicine and e-health systems: A case study of England’s shared electronic health record system

open access: yes, 2010
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 9/11/2010.Shared electronic health record (EHR) systems constitute an important Telemedicine and e-Health application. Successful implementation of shared
Mohammad, Yara Mahmoud
core  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Role of Patient Identification in Patient Safety [PDF]

open access: yes, 2007
Matching the right patient with the right care is at the heart of safe healthcare. Patient wristbands form a vital link between the patient, local information systems, care delivery and the wider healthcare system.
Ranger, Chris   +4 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Large scale organisational intervention to improve patient safety in four UK hospitals: mixed method evaluation [PDF]

open access: yes, 2011
Objectives To conduct an independent evaluation of the first phase of the Health Foundation’s Safer Patients Initiative (SPI), and to identify the net additional effect of SPI and any differences in changes in participating and non-participating NHS ...
A. Benning   +78 more
core   +1 more source

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