Results 161 to 170 of about 21,438,871 (300)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Accuracy of day-to-day patient positioning in ocular proton therapy with a dedicated beamline. [PDF]

PLoS One
Hol M, Spruijt KH, Rodrigues MF, Klaver YLB, Kouwenberg J, Bakker PAC, Luyten GPM, Kiliç E, Beenakker JM, Astreinidou E, Rasch CRN.   +10 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Motion study on upright patient positioning in walk-through PET: evaluation in a clinical setting. [PDF]

EJNMMI Phys
Aziz R, Muller FM, Withofs N, Maebe J, Dadgar M, Vervenne B, D'Asseler Y, Vanhove C, Vandenberghe S.   +8 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Impact of patient positioning on hemodynamic assessment: A comparison of supine and upright right heart catheterization. [PDF]

Physiol Rep
Chowdhury MA, Squires J, Systrom DM, Waxman AB.   +3 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Randomized Controlled Trial of Patient Positioning and Operator Radiation Exposure During Lower Extremity Catheter Angiography. [PDF]

Life (Basel)
Bérczi Á, Szablics FÉ, Simon AN, Taba G, Papp DÁ, György R, Pataki ÁA, Hüttl A, Nemes B, Csobay-Novák C.   +9 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Simplified technique of patient positioning and renal access in true supine percutaneous nephrolithotomy. [PDF]

Urol Ann
Dixit VK, Gupta A, Vijjan VK, Sharma K, Kumar A, Pruthi S, Sethi Y.   +6 more
europepmc   +1 more source