Results 221 to 230 of about 21,438,871 (300)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Patient positioning in minimally invasive gynecologic surgery: strategies to prevent injuries and improve outcomes. [PDF]

Rev Bras Ginecol Obstet
Lopes da Silva A, Eduardo Soares Pinhati M, Lage Neves G, Naves Gonçalves de Almeida E, Lamaita Lopes T, Mara Lamaita R, Batista Cândido E.   +6 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

The Effect of Intraoperative Patient Positioning on the Success of Intertrochanteric Fracture Surgery in Older Patients. [PDF]

Medicina (Kaunas)
Kaya O, Kundakçı B, Önder C, Kurt V, Atmaca E, Tunç F.   +5 more
europepmc   +1 more source

Basics of Shoulder Arthroscopy Part III: Lateral Decubitus Patient Positioning and Operating Room Setup. [PDF]

Arthrosc Tech
Ulrich MN, Meta F, Pan X, Okoroha KR, Camp CL.   +4 more
europepmc   +1 more source

Basics of Shoulder Arthroscopy Part I: Beach-Chair Patient Positioning and Operating Room Setup. [PDF]

Arthrosc Tech
Meta F, Ulrich MN, Simon KN, Tagliero AJ, Camp CL.   +4 more
europepmc   +1 more source

The impact of a prophylactic skin dressing on surface-guided patient positioning in chest wall Radiation Therapy. [PDF]

J Med Radiat Sci
Cumming J, Thompson K, Woodford K, Panettieri V, Sapkaroski D.   +4 more
europepmc   +1 more source

Effect of Patient Positioning on CT Number Accuracy: A Phantom Study Comparing Energy Integrating and Deep Silicon Photon Counting Detector CT. [PDF]

J Comput Assist Tomogr
Salyapongse AM, Rose SD, Pickhardt PJ, Lubner MG, Toia GV, Bujila R, Yin Z, Slavic S, Szczykutowicz TP.   +8 more
europepmc   +1 more source