Results 251 to 260 of about 465,365 (351)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Basics of Ankle Arthroscopy Part 3: Patient Positioning and Preparation for Posterior Ankle Arthroscopy. [PDF]

Arthrosc Tech
Butler JJ, Resad S, Samsonov AP, Cole WW, Connolly P, Robin JX, Krebsbach S, Kennedy JG.   +7 more
europepmc   +1 more source

A convenient, reliable, and fast acoustic pressure field measurement method for magnetic resonance-guided high-intensity focused ultrasound systems with phased array transducers [PDF]

, 2018
Altman, Michael B, Chen, Hong, Gach, H Michael, Hallahan, Dennis E, Kothapalli, Satya V.V.N., Partanen, Ari, Zhu, Lifei   +6 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Basics of Ankle Arthroscopy Part 1: Patient Positioning and Preparation for Anterior Ankle Arthroscopy. [PDF]

Arthrosc Tech
Lehane K, Butler JJ, Lowe D, Samsonov AP, Krebsbach S, Perez J, Bloom DA, Kennedy JG.   +7 more
europepmc   +1 more source

Auditory Brainstem Implant Array Position Varies Widely Among Adult and Pediatric Patients and Is Associated With Perception

, 2017
Samuel R. Barber, Elliott D. Kozin, Aaron K. Remenschneider, Sidharth V. Puram, Max Kailler Smith, Barbara S. Herrmann, Mary E. Cunnane, M. Christian Brown, Daniel J. Lee   +8 more
openalex   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Automated robotic-assisted patient positioning method and dosimetric impact analysis for boron neutron capture therapy. [PDF]

Sci Rep
Chen J, Teng YC, Shu D, Gong Q, Xie Q, Liu YH.   +5 more
europepmc   +1 more source

Patient Positioning System [PDF]

Biomedical Safety & Standards, 2009
openaire   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source