Results 61 to 70 of about 18,470 (294)

Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A

Advanced Science, EarlyView.
Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou, Li Lin, Mengjie Xia, Ruohan Liang, Yueyue Zhang, Linna Du, Xuan Cao   +6 more
wiley   +1 more source

Re-Forming Reform Part II: Implementing the Affordable Care Act in Massachusetts

, 2017
Client/Partner: Blue Cross Blue Shield of Massachusetts FoundationIn April of 2006, Massachusetts enacted its landmark health reform, Chapter 58 of the Acts of 2006, An Act Providing Access to Affordable, Quality, Accountable Health Care.
Rodman, Elisabeth, Seifert, Robert W.
core  

Adaptive Conductive Systems: Enabling Deformable Electronics Through Engineered Materials, Circuits, and Intelligent Systems

Advanced Science, EarlyView.
This review presents the research advances of adaptive conductive systems from the perspective of materials, circuits, systems, and applications. Deformable conductors consist of substrates/matrices and conductive materials, structural design of circuit interconnections, fabrication of circuit interconnections, as well as intelligent systems ...
Yufei Lu, Siyu Liang, Jingyi Niu, Jie Chen, Shuo Zhang, Hongjian Zhang, Dongsheng Jia, Wei Huang   +7 more
wiley   +1 more source

Patient Protection and Affordable Care Act: Annual Fee on Health Insurers [PDF]

, 2013
This report discusses the Patient Protection and Affordable Care Act (ACA, P.L. 111-148) and the Reconciliation Act of 2010 (P.L.
Kirchhoff, Suzanne M.
core  

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Why Employers Will Continue to Provide Health Insurance: The Impact of the Affordable Care Act

Inquiry: The Journal of Health Care Organization, Provision, and Financing, 2012
The Congressional Budget Office, the Rand Corporation, and the Urban Institute have estimated that the Patient Protection and Affordable Care Act (ACA) will leave employer-sponsored coverage largely intact; in contrast, some economists and benefit ...
Linda J. Blumberg, Matthew Buettgens, Judith Feder, John Holahan   +3 more
doaj   +1 more source

Racial disparities in cancer mortality in the United States, 2000-2010

Frontiers in Public Health, 2015
Declining cancer incidence and mortality rates in the United States (U.S.) have continued through the first decade of the twenty-first century. Reductions in tobacco use, greater uptake of prevention measures, adoption of early-detection methods, and ...
Eileen B O'keefe
doaj   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

The Impact of The Patient Protection and Affordable Care Act on Patient Physician Relationships

, 2014
The Patient Protection and Affordable Care Act (PPACA), a United States federal statue signed into law on March 23, 2010, includes various reforms that cause a potential threat to patient physician relationships.
Murphy, Kelsey
core   +1 more source

Why are Low-Income Teens More Likely to Lack Health Insurance Than Their Younger Peers?

Inquiry: The Journal of Health Care Organization, Provision, and Financing, 2011
Low-income teenagers are more likely to lack health insurance than younger children. Using data from the 2006, 2007, and 2008 rounds of the National Health Interview Survey, we examine whether differences between teens and younger children in ...
Lindsey Jeanne Leininger, Marguerite E. Burns   +1 more
doaj   +1 more source