Results 121 to 130 of about 10,730,196 (305)

Disease control and quality of life in chronic spontaneous urticaria and recurrent angioedema are strongly linked, but not in all patients

Clinical and Translational Allergy
Background Patient‐reported outcome measures (PROMs) help to assess disease control and quality of life (QoL) in chronic spontaneous urticaria (CSU) and recurrent angioedema (RA). This study aimed to assess the correlation between two different concepts:
Sophia Neisinger, Pascale Salameh, Annika Gutsche, Felix Aulenbacher, Frank Siebenhaar, Marcus Maurer   +5 more
doaj   +1 more source

Development and Validation of a Patient-Reported Outcome Measure for Fingernail and Toenail Conditions: The NAIL-Q

, 2023
Anne F Klassen,1 Charlene Rae,1 Maureen O’Malley,2 Trisia Breitkopf,1 Leah Algu,1 Jasmine Mansouri,3 Claire R Brown,4 Yi Wang,5 Shari R Lipner4 1Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada; 2Division of Dermatology ...
Breitkopf T, Mansouri J, Brown CR, O'Malley M, Rae C, Algu L, Lipner SR, Klassen AF, Wang Y   +8 more
core  

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Patient-reported outcome scores before and after total joint arthroplasty.

, 2019
Patient-reported outcome scores before and after total joint arthroplasty.
Anne Lübbeke (3918686), Didier Hannouche (329493), Hermès H. Miozzari (6808205), Thomas V. Perneger (211367)   +3 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Sexual health—a topic for cancer patients receiving oncological treatment with palliative intent

BMC Palliative Care
Objectives Sexuality is an important dimension of health-related quality of life (HRQOL) in cancer patients. Studies evidence that most patients report impairments of their sexual health related to their disease or its treatment.
Claudia Schmalz, Anne S. Oberguggenberger, Eva Nagele, Brigitte Bliem, Anne Lanceley, Andy Nordin, Karin Kuljanic, Pernille T. Jensen, Vesna Bjelic-Radisic, Alexander Fabian, Juan I. Arraras, Chie Wei-Chu, Carien L. Creutzberg, Razvan Galalae, Hilde Toelen, Kristin Zimmermann, Anna Costantini, Thierry Almont, Samantha Serpentini, Ligita Paskeviciute Frøding, Ingvild Vistad, Krzysztof A. Tomaszewski, Elisabeth Inwald, Elfriede Greimel, the EORTC Quality of Life Group   +24 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source