Results 221 to 230 of about 10,730,196 (305)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Validating the ADFSCI hypotension symptom domain as a scalable patient reported outcome measure in spinal cord injury. [PDF]

NPJ Digit Med
Yang W, Smith MN, Rimok J, Gandhi AP, Hankov N, Macellari N, Nijland AEJ, van Nes IJW, Asboth L, Squair J, Bloch J, Langerak NG, Keijsers NLW, Kurt E, Huh S, Larkin-Kaiser KA, Wecht JM, McKenna SL, Courtine G, Phillips AA.   +19 more
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

The Parkinson's Disease-Health Index: A novel, disease-specific patient-reported outcome measure. [PDF]

J Parkinsons Dis
Seabury J, Weinstein J, Rosero S, Varma A, Engebrecht C, Heatwole J, Zizzi C, Dilek N, Arky A, Ray Dorsey E, Heatwole C.   +10 more
europepmc   +1 more source

Patient Reported Outcome Measurements

Journal of Pharmaceutical Research, 2015
openaire   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Development and validation of the Life after Stroke questionnaire as a patient-reported outcome measure for stroke survivors living at home. [PDF]

Sci Rep
Brunner W, Zenzmaier C, Huber N, Granna J, Mölgg K, Dejakum B, Felicetti S, Karisik A, Kiechl S, Boehme C, Knoflach M.   +10 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

The Development and Initial Psychometric Testing of a Patient-Reported Outcome Measure to Assess COPD-Related Emotional Distress. [PDF]

Int J Chron Obstruct Pulmon Dis
Schmid-Mohler G, Hübsch C, Mueller M, Imhof R, Jordan KD, Clarenbach C, Monsch GM, Yorke J.   +7 more
europepmc   +1 more source