Results 71 to 80 of about 1,030,601 (304)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Patient reported outcome measures in rare diseases: a narrative review

Orphanet Journal of Rare Diseases, 2018
BackgroundRare diseases can lead to a significant reduction in quality of life for patients and their families. Ensuring the patients voice is central to clinical decision making is key to delivering, evaluating and understanding the efficacy of ...
A. Slade, Fatima Isa, Derek G Kyte, T. Pankhurst, L. Kerecuk, J. Ferguson, G. Lipkin, M. Calvert   +7 more
semanticscholar   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Functional Assessment of Chronic Illness Therapy-Fatigue is a reliable and valid measure in patients with active ankylosing spondylitis

Journal of Patient-Reported Outcomes, 2022
Plain English summary Ankylosing spondylitis (AS) is a disease that causes pain and stiffness in the spine. AS is a chronic disease. Most people with AS experience fatigue (a feeling of being very tired or exhausted).
David Cella, William R. Lenderking, Peter Chongpinitchai, Andrew G. Bushmakin, Oluwaseyi Dina, Lisy Wang, Joseph C. Cappelleri, Victoria Navarro-Compán   +7 more
doaj   +1 more source

Web-Based Patient-Reported Outcome Measures for Personalized Treatment and Care (PROMPT-Care): Multicenter Pragmatic Nonrandomized Trial

Journal of Medical Internet Research, 2020
Background Despite the acceptability and efficacy of e–patient-reported outcome (ePRO) systems, implementation in routine clinical care remains challenging. Objective This pragmatic trial implemented the PROMPT-Care (Patient Reported Outcome Measures for
A. Girgis, I. Durcinoska, A. Arnold, J. Descallar, N. Kaadan, E. Koh, Andre Miller, Weng Ng, M. Carolan, S. Della-Fiorentina, S. Avery, G. Delaney   +11 more
semanticscholar   +1 more source

Measuring Patient-Reported Outcomes Adaptively: Multidimensionality Matters! [PDF]

Applied Psychological Measurement, 2017
As there is currently a marked increase in the use of both unidimensional (UCAT) and multidimensional computerized adaptive testing (MCAT) in psychological and health measurement, the main aim of the present study is to assess the incremental value of using MCAT rather than separate UCATs for each dimension.
Paap, Muirne C. S., Kroeze, Karel A., Glas, Cees A.W., Terwee, Caroline B., van der Palen, Job, Veldkamp, Bernard P   +5 more
openaire   +7 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Patient-reported outcomes after hip and knee arthroplasty: results from a large national registry

Bone & Joint Open, 2021
Aims: This study aims to describe the pre- and postoperative self-reported health and quality of life from a national cohort of patients undergoing elective total conventional hip arthroplasty (THA) and total knee arthroplasty (TKA) in Australia.
Emma Louise Heath, Ilana N. Ackerman, Kara Cashman, Michelle Lorimer, Stephen E. Graves, Ian A. Harris   +5 more
doaj   +1 more source

Patient‐reported outcome measures ( PROMs): making sense of individual PROM scores and changes in PROM scores over time

Nephrology, 2020
Patient‐reported outcome measures (PROMs) are increasingly being used in nephrology care. However, in contrast to well‐known clinical measures such as blood pressure, health‐care professionals are less familiar with PROMs and the interpretation of PROM ...
E. M. van der Willik, C. Terwee, W. Bos, M. Hemmelder, K. Jager, C. Zoccali, F. Dekker, Y. Meuleman   +7 more
semanticscholar   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source