Results 31 to 40 of about 1,191,077 (268)

Effectiveness and Safety of Antithrombotic Medication in Patients With Atrial Fibrillation and Intracranial Hemorrhage: Systematic Review and Meta-Analysis [PDF]

, 2022
Elena Ivany, Leona A. Ritchie, Gregory Y.H. Lip, Robyn Lotto, David J. Werring, Deirdre A. Lane   +5 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Axillary lymph node recurrence following wire‐directed sentinel lymph node dissection for breast cancer patients with biopsy‐proven axillary metastases prior to neoadjuvant chemotherapy at a safety net medical center [PDF]

, 2023
Rachel E. Sargent, Emily Siegel, Fumito Ito, Katherine Kramme, Elizabeth Kraft, Vera Hendrix, Azadeh A. Carr, Maria Nelson, Shelly X. Bian, Priya Jayachandran, Stephen Sener   +10 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Inpatient Suicide Prevention: A Review of the Patient Safety Authority’s Keys to Ligature Risk Assessment Project

Patient Safety, 2019
It takes less than five minutes and 18 inches from the ground for a person to self-asphyxiate from hanging.1 According to the American Foundation for Suicide Prevention (AFSP), suicide is currently the 10th leading cause of death in the United States and
Christopher Mamrol, Melanie A. Motts, Richard Kundravi   +2 more
doaj   +1 more source

Data Snapshot: Nasogastric Tube Misplacements

Patient Safety, 2021
Nasogastric and orogastric tubes, herein collectively referred to as nasogastric tubes (NGT), are inserted into a patient’s nasal or oral cavity to administer feedings or medications or remove stomach contents.1 Tube misplacement is a known complication ...
Lea Anne Gardner, Susan Wallace
doaj   +1 more source

Label extension, single-arm, phase III study shows efficacy and safety of stempeucel® in patients with critical limb ischemia due to atherosclerotic peripheral arterial disease [PDF]

, 2023
Pawan Kumar Gupta, P Shivashankar, M Rajkumar, Subhendu Sekhar Mahapatra, Sanjay C Desai, Anita Dhar, Vinay Krishna, N. S. Raviraja, Samatha Bhat, Pachaiyappan Viswanathan, Suresh Kannan, Jijy Abraham, Hema Boggarapu, M. S. Manjuprasad, Karthika Priyadharshini Udaykumar   +14 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

1373P Efficacy and safety of taletrectinib in patients (Pts) with ROS1+ non-small cell lung cancer (NSCLC): Interim analysis of global TRUST-II study [PDF]

, 2023
M. Pérol, Nong Yang, C-M. Choi, Yuichiro Ohe, Shunichi Sugawara, Noriko Yanagitani, Geoffrey Liu, Filippo de Braud, Jorge J. Nieva, Misako Nagasaka, Lyudmila Bazhenova, Caicun Zhou, Enriqueta Felip, X. Zhang, S. Li, Nathan A. Pennell   +15 more
openalex   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source