Results 311 to 320 of about 16,562,700 (402)

EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy

open access: yesAdvanced Science, EarlyView.
This review provides new perspectives on EGFR's activation, mutations, and their impact on tumor immunotherapy. It summarizes how EGFR is activated and the current EGFR targeting strategy, evaluates their clinical outcomes in combination with immunotherapy, highlighting differential responses in tumors with EGFR wild‐type and different mutants.
Yuanzhuo Gu   +7 more
wiley   +1 more source

Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia

open access: yesAdvanced Science, EarlyView.
Plasma metabolic detection combined with machine learning offers a precise (area under the curve of 0.874) and high‐throughput (<30 s) diagnosis for pathologic myopia (serious myopic macular degeneration). The biomarkers indicate the pathologic myopia‐associated systemic metabolic reprogramming, which exhibits specificity for myopic macular ...
Ziheng Qi   +13 more
wiley   +1 more source

Remimazolam for procedural sedation in the emergency department: a prospective study of effectiveness and patient satisfaction. [PDF]

open access: yesScand J Trauma Resusc Emerg Med
Andreassen S   +6 more
europepmc   +1 more source

Volumetric Engineered 3D Drug Reservoir Against Diabetic Implant Infection via Cuproptosis‐Like Bacterial Death and Hunger‐Triggered Maintenance of Mitochondrial Integrity

open access: yesAdvanced Science, EarlyView.
This study provides a volumetric engineered 3D drug reservoir to combat diabetic implant infection. Cu‐doped quantum dots induce cuproptosis‐like bacterial death via metabolic collapse, while glucose oxidase triggers hunger‐triggered mitochondrial protection in host cells.
Dize Li   +8 more
wiley   +1 more source

Chronically Stable, High‐Resolution Micro‐Electrocorticographic Brain‐Computer Interfaces for Real‐Time Motor Decoding

open access: yesAdvanced Science, EarlyView.
A high‐resolution micro‐electrocorticographic (µECoG) brain‐computer interface (BCI) for real‐time motor decoding is reported. The application of flexible, scalable µECoG electrode arrays overcomes the insufficient spatial resolution in conventional ECoG BCIs.
Erda Zhou   +15 more
wiley   +1 more source

Cascade‐Targeted Nanoparticles for Enhanced Gemcitabine Delivery and Adenosine Metabolism Modulation to Overcome Treatment Resistance in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
The aberrant adenosine metabolism leads to chemoresistance and immunosuppressive microenvironment. A versatile albumin‐polyplexes conjugated nanoparticle B‐PDEA@CPA is prepare for the codelivery of gemcitabine and siCD39. The nanoparticle releases gemcitabine‐loaded albumin upon microenvironment to achieve promoted penetration and cellular uptake ...
Hongrui Fan   +10 more
wiley   +1 more source

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