Results 161 to 170 of about 6,688,553 (311)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Algorithms of Patient Selection for Allergen Immunotherapy. [PDF]

Allergy
Zieglmayer UP, Arasi S, Eiwegger T, Jakob T, Klimek L, Ollert M.   +5 more
europepmc   +1 more source

Holmium laser enucleation of the prostate: patient selection and perspectives

, 2016
Tracy Marien, Mustafa Kadihasanoglu, Nicole L Miller Department of Urology, Vanderbilt Medical Center, Nashville, TN, USA Background: Multiple endoscopic surgical options exist to treat benign prostatic hyperplasia (BPH), including holmium ...
Kadihasanoglu M, Miller NL, Marien T
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Breast-Conserving Surgery in Multicentric Breast Cancer: Evolving Evidence and Patient Selection. [PDF]

Cancers (Basel)
Rizk M, Mokbel K.
europepmc   +1 more source

Quality and Patient Safety Division Annual Report 2013

, 2014
A work plan is developed on an annual basis to support the quality and patient safety objectives in the National Service Plan.
Quality and Patient Safety Division
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Diagnostic discordance in outside prostate biopsies: Implications for active surveillance patient selection. [PDF]

Investig Clin Urol
Park HJ, Park JH, Chung Y, Kim HJ, Lee H, Oh JJ, Lee S, Jeong SJ, Hong SK, Byun SS, Song SH.   +10 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Reply to the editor: patient selection and multimodality therapy in stage IV esophageal adenocarcinoma. [PDF]

J Thorac Dis
Sewell M, Molena D.
europepmc   +1 more source