Results 281 to 290 of about 2,641,102 (341)

Enhanced patient selection with quantitative continuous scoring of PD-L1 expression for IO treatment in metastatic NSCLC. [PDF]

NPJ Precis Oncol
Lesniak J, Schick M, Kunzke T, Pollastri F, Vigueras-Guillén JP, Hessel H, Haneder S, Sontakke P, DaCosta K, Alleze R, Zimmermann J, Kapil A, Brieu N, Shumilov A, Sade H, Barrett JC, Schmidt G, Stewart R.   +17 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Proton Therapy Patient Selection Methods and the Impact of COVID-19: A Cross-Sectional International Survey. [PDF]

J Med Radiat Sci
Wood L, Giles E, Cunningham L, Le H, Zientara N, Short M.   +5 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

NTCP-Based Prediction of Lung Sparing With IMPT in BC Patients and Implication of Patient Selection. [PDF]

Int J Part Ther
Wu XY, Chen M, Cai G, Cai R, Xu C, Ou D, Xu FF, Wang YJ, Li H, Li M, Zhang YB, Cao L, Chen JY.   +12 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Liver Transplantation for Colorectal Metastases: Impact of a Standardised Protocol for Patient Selection on Transplant Outcomes. [PDF]

Cancers (Basel)
Stocco A, Laurenzi A, Serenari M, Prosperi E, Fallani G, Bonatti C, Radi G, Prior M, Odaldi F, Zanfi C, Mirici Cappa F, Siniscalchi A, Morelli MC, Ravaioli M, Cescon M.   +14 more
europepmc   +1 more source

Patient-Selection of a Clinical Trial Primary Outcome: The ENHANCE-AF Outcomes Survey. [PDF]

PLoS One
Stafford RS, Rice EN, Shah R, Hills MT, Nunes JC, DeSutter K, Lin A, Lhamo K, Lin B, Lu Y, Wang PJ.   +10 more
europepmc   +1 more source

Novel device therapies in heart failure: focus on patient selection. [PDF]

Front Cardiovasc Med
Balgobind A, Asemota D, Rodriguez E, Wattanachayakul P, Fudim M, Alvarez Villela M.   +5 more
europepmc   +1 more source