Results 61 to 70 of about 85,512 (248)

Use of a plastic scintillator detector for patient‐specific quality assurance of VMAT SRS [PDF]

Journal of Applied Clinical Medical Physics, 2019
AbstractPurposeTo evaluate a scintillator detector for patient‐specific quality assurance of VMAT radiosurgery plans.MethodsThe detector was comprised of a 1 mm diameter, 1 mm high scintillator coupled to an acrylic optical fiber. Sixty VMAT SRS plans for treatment of single targets having sizes ranging from 3 mm to 30.2 mm equivalent diameter (median ...
Snyder, Jesse D., Sullivan, Rodney J., Wu, Xingen, Covington, Elizabeth L., Popple, Richard A.   +4 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Patient-Specific quality assurance protocol for volumetric modulated arc therapy using dose volume histogram

Journal of Medical Physics, 2018
A retrospective study was performed to explore the use of dose volume histogram (DVH) metrics in a patient-specific quality assurance protocol for volumetric modulated arc therapy (VMAT).
Christopher Low, Warren Toye, Peter Phung, Christopher Huston   +3 more
doaj   +1 more source

Pretreatment patient-specific quality assurance prediction based on 1D complexity metrics and 3D planning dose: classification, gamma passing rates, and DVH metrics

Radiation Oncology, 2023
Purpose Highly modulated radiotherapy plans aim to achieve target conformality and spare organs at risk, but the high complexity of the plan may increase the uncertainty of treatment.
Liyuan Chen, Huanli Luo, Shi Li, Xia Tan, Bin Feng, Xin Yang, Ying Wang, Fu Jin   +7 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Evaluation of 2D ion chamber arrays for patient specific quality assurance using a static phantom at a 0.35 T MR-Linac

Zeitschrift für Medizinische Physik
Introduction: Patient specific quality assurance (QA) in MR-Linacs can be performed with MR-compatible ion chamber arrays. However, the presence of a static magnetic field can alter the angular response of such arrays substantially.
C. Katharina Renkamp, Daniela Eulenstein, Moritz Sebald, Fabian Schlüter, Carolin Buchele, Carolin Rippke, Jürgen P. Debus, Sebastian Klüter   +7 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Impact of log file source and data frequency on accuracy of log file-based patient specific quality assurance

Zeitschrift für Medizinische Physik
Performing phantom measurements for patient-specific quality assurance (PSQA) adds a significant amount of time to the adaptive radiotherapy procedure. Log file based PSQA can be used to increase the efficiency of this process.
Akbar Azzi, Gerd Heilemann, Dietmar Georg, Supriyanto Ardjo Pawiro, Terry Mart, Wolfgang Lechner   +5 more
doaj   +1 more source

Prediction models as decision-support tools for virtual patient-specific quality assurance of helical tomotherapy plans

Physics and Imaging in Radiation Oncology, 2023
Background and purpose: Prediction models may be reliable decision-support tools to reduce the workload associated with the measurement-based patient-specific quality assurance (PSQA) of radiotherapy plans.
Samuele Cavinato, Andrea Bettinelli, Francesca Dusi, Marco Fusella, Alessandra Germani, Francesca Marturano, Marta Paiusco, Nicola Pivato, Marco Andrea Rossato, Alessandro Scaggion   +9 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source