Results 251 to 260 of about 1,574,000 (316)

Mutational accumulation drives pathway dysregulation to predict glioma patient survival. [PDF]

Sci Rep
Wan M, Zhuang C, Li W, Yan R, Chen W, Cheng J, Yue C, Chen L, Quan Y.   +8 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A Radiomic Model for Gliomas Grade and Patient Survival Prediction. [PDF]

Bioengineering (Basel)
Chaddad A, Jia P, Hu Y, Katib Y, Kateb R, Daqqaq TS.   +5 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Spatial distribution analysis of tertiary lymphoid structures in esophageal squamous cell carcinoma predicts patient survival and response to neoadjuvant chemo-immunotherapy. [PDF]

J Transl Med
Wang L, Li J, Ao Y, Yu Y, Zhai J, Zhang Y, Wu L, Hao J, Hu Y, Wang Q, Yin F, Liu T.   +11 more
europepmc   +1 more source

Survival of patients with cancer.

BMJ, 1989
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Tumor necrosis associates with aggressive breast cancer features, increased hypoxia signaling and reduced patient survival. [PDF]

Sci Rep
Syrtveit AA, Ingebriktsen LM, Tegnander AF, Akslen LA, Wik E, Hoivik EA.   +5 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Defining endpoints in percutaneous cholecystostomy: Catheter management, patient survival, and long-term outcomes from a twelve-year retrospective study. [PDF]

World J Gastrointest Surg
Hassanesfahani M, Giannis D, Marfo N, Kaur M, Quang CMT, Miele A, Louis MA, Mandava NR.   +7 more
europepmc   +1 more source