Results 111 to 120 of about 9,092,823 (213)

A tumour‐associated macrophage‐based signature for deciphering prognosis and immunotherapy response in prostate cancer

IET Systems Biology
For the multistage progression of prostate cancer (PCa) and resistance to immunotherapy, tumour‐associated macrophage is an essential contributor. Although immunotherapy is an important and promising treatment modality for cancer, most patients with PCa ...
Jian Wang, Tao Guo, Yuanyuan Mi, Xiangyu Meng, Shuang Xu, Feng Dai, Chengwen Sun, Yi Huang, Jun Wang, Lijie Zhu, Jianquan Hou, Sheng Wu   +11 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Patient perceptions of multiple sclerosis and its treatment

, 2012
Jérôme de Seze1, Florent Borgel2, Frédérique Brudon31Department of Neurology CHRU de Strasbourg, Strasbourg, 2Medical Center, Grenoble, 3Clinique du Tonkin, Villeurbanne, FranceBackground: In order to improve ...
de Seze J, Borgel F, Brudon F
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Defining score interpretation thresholds for clinical outcome assessments: a review of terminology and reporting recommendations

Journal of Patient-Reported Outcomes
Purpose The concept of ‘score interpretation threshold’ for understanding score differences of clinical outcome assessments (COAs) and terminology around this topic have evolved over several decades.
E. Flood, N. Clarke, B. L. King-Kallimanis, J. Musoro, S. Eremenco, C. L. Ward, J. C. Cappelleri, S. Nolte   +7 more
doaj   +1 more source

Managing complexities of inflammatory rheumatic diseases as a migrant—a qualitative exploration of health literacy experiences

Frontiers in Public Health
BackgroundMigrants comprise over 17% of Norway’s population and are at increased risk of limited health literacy, a key determinant of health. Health literacy is shaped by language, culture, social norms, discrimination, and health system responsiveness.
Laura Treacy, Laura Treacy, Lise-Merete Alpers, Sarah Hakim, Maryam Azimi, Heidi A. Zangi, Heidi A. Zangi   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Patient Safety Report Program

This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Began with 2011; ceased with 2012Includes bibliographical ...

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