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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source

Assessment of the acoustical standards in patient care units in Jordanian National Hospitals in light of the international criteria: Case of King Abdullah University Hospital

Alexandria Engineering Journal, 2019
The medical functionality of hospitals is essential in the healing process in patients’ wards. The acoustical environment in the hospital needs to be investigated to achieve the best level of patients' acoustical comfort.
Hussain H. Alzoubi, Ahmed S. Attia
doaj +1 more source

Addressing the Quality and Safety Gap Part I: Case Studies in Transforming Hospital Nursing and Building Cultures of Safety [PDF]

, 2009
Presents case studies of strategies four healthcare systems and a state government are using to address underlying causes in flawed systems: strengthening care processes, optimizing staffing, and promoting safe work habits.

core

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source

Flexibility in hospital building and application by means of standardized medical room types [PDF]

, 2014
This paper presents an approach to standardization of hospital rooms. As hospitals are becoming more complex, the need for quality assurance and validation increases as well.
Ankersmid, H.A.H.G. +3 more
core +1 more source

Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine [PDF]

, 2003
OBJECTIVE: To compare two widely used drug treatments for people with aggression or agitation due to mental illness. DESIGN: Pragmatic, randomised clinical trial. SETTING: Three psychiatric emergency rooms in Rio de Janeiro, Brazil. SUBJECTS:
Abreu, A.M. +13 more
core +1 more source

Interprofessional team assessments of the patient safety climate in Swedish operating rooms: a cross-sectional survey [PDF]