Results 101 to 110 of about 848,134 (218)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The survey of the effect of ginger extract on gastric residual volume in mechanically ventilated patients hospitalized in the Intensive Care Units [PDF]

, 2013
Background and purpose: Delayed gastric emptying in mechanically ventilated patients is common. According to evidences, Ginger can accelerate gastric emptying.
Ali Vakili, M., Amin, G., Eshghi Nia, S., Ghochae, A., Hekmat Fshar, M., Jouybari, L., Sanagoo, A.   +6 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

EMERGENCY PATIENTS RIGHTS AND DIGNITY IN BULGARIA

Journal of IMAB, 2017
In addition to the emergency medical services the victims of various disasters and accidents need to keep their dignity as human beings. Dignity is a term used in morals and ethics to designate that people have the right to be respected and treated ...
Desislava Todorova, Svetoslav Garov, Tsvetelina Mihailova   +2 more
doaj   +1 more source

The use of fibrinogen concentrate for the management of trauma-related bleeding. A systematic review and meta-analysis [PDF]

, 2017
Haemorrhage following injury is associated with significant morbidity and mortality. The role of fibrinogen concentrate in trauma-induced coagulopathy has been the object of intense research in the last 10 years and has been systematically analysed in ...
Franchini, Massimo, Liumbruno, Giancarlo M., Marano, Giuseppe, Marietta, Marco, Mengoli, Carlo, Pupella, Simonetta, Vaglio, Stefania   +6 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Caught between rights and realities: Nurses’ challenges with upholding patients’ rights in selected health facilities of South Africa

Health SA Gesondheid: Journal of Interdisciplinary Health Sciences
Background: Nurses play a central role in upholding patients’ rights; yet in many health facilities, these rights are frequently compromised. Understanding these challenges is essential for developing effective improvement strategies and ensuring ethical,
Adolphina M. Thema, Fhumulani M. Mulaudzi, Ndivhaleni R. Lavhelani, Sinethemba Nyandeni, Maurine R. Musie   +4 more
doaj   +1 more source

Awareness of, responsiveness to and practice of patients’ rights at Uganda’s national referral hospital

African Journal of Primary Health Care & Family Medicine, 2013
Background: The realisation of patients’ rights in resource-constrained and patient-burdened public health care settings in Uganda remains an obstacle towards quality health care delivery, health care seeking behaviour and health outcomes.
Harriet R. Kagoya, Dan Kibuule, Honoré Mitonga-Kabwebwe, Elizabeth Ekirapa-Kiracho, John C. Ssempebwa   +4 more
doaj   +1 more source

Splenectomy and Thymectomy in Human Renal Homotransplantation [PDF]

, 1963
Five patients with terminal renal failure have been treated with renal homografts. Total body irradiation and cytotoxic drugs were used to prevent rejection.
Marchioro, TL, Starzl, TE, Talmage, DW, Waddell, WR   +3 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source