Results 51 to 60 of about 18,923 (271)
Advanced Science, EarlyView.Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun +14 more
wiley +1 more source
Neopatrimonial Rule through Formal Institutions: The Case of Turkey
Government and OppositionThis study examines how formal institutions in hybrid regimes, particularly presidentialism, party organization and electoral rules, actively foster and sustain clientelistic networks, leading to particularistic outcomes.
Eda Bektas
doaj +1 more source
Advanced Science, EarlyView.This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong +15 more
wiley +1 more source
Rui Barbosa e a razão clientelista
Dados: Revista de Ciências Sociais, 2000 In a discussion of the patron-client relation within Brazilian politics, the article takes as an example political favors asked of Rui Barbosa when he was the provisional government's Minister of the Treasury.
Carvalho José Murilo de
doaj
The patron-client relation in fishermen community
International Journal of Academic Research, 2014 - This Study aim s to reveal...
openaire +3 more sources
Advanced Science, EarlyView.BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou +9 more
wiley +1 more source
The Maltese nobility during the Hospitaller period : towards a reappraisal [PDF]
, 2011 Over the last thirty years the nobilities of early modern Europe have become a subject of major interest for historians working on the social history of the period. This increase in attention has resulted in the development of new approaches to what is
Caruana Galizia, Anton
core
The Political Economy of Inclusive Growth [PDF]
, 2012 An Application of Political Settlements to the case of ...
Khan, Mushtaq
core +1 more source
Advanced Science, EarlyView.This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu +14 more
wiley +1 more source
Determinants of Corruption in Developing Countries: the Limits of Conventional Economic Analysis [PDF]
, 2006 Corruption takes place when public officials break the law in pursuit of their private interest. But public officials can break different laws in different ways with different implications for the public good.
Khan, Mushtaq
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