Results 131 to 140 of about 355,043 (324)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Patrons [PDF]

open access: yes2018 IEEE Globecom Workshops (GC Wkshps), 2018
openaire   +2 more sources

Financing of Initiatives to Commemorate the Patron of a Local or Regional Community with Public Funds, Including from the So-Called Participatory Budget

open access: yesStudies in Logic, Grammar and Rhetoric
The purpose of this paper is to describe the basic legal solutions that can be used to finance initiatives to commemorate the patron of a local or regional community.
Popławski Mariusz
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Saints and Non-Saints. Patronage in Hanging Cultural and Political Conditions

open access: yesStudies in Logic, Grammar and Rhetoric
Patrons have played a very important role in the past not only in re-ligious terms, but also as a keystone connecting local communities and even dif-ferent countries. They therefore influenced international relations. Today, they still play a role at the
Bartnicki Adam R.
doaj   +1 more source

Etiología microbiana y patrones de resistencia actuales en la colecistitis aguda litiásica [PDF]

open access: green
Maite de Miguel-Palacio   +7 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

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