Results 161 to 170 of about 67,421 (252)

[Bronchiolitis Obliterans Associated with Graft-Versus-Host Disease: an Underdiagnosed Complication that Requires Structured Respiratory Surveillance]. [PDF]

Open Respir Arch
Mora-Cuesta VM, Pérez Rojo R, Rodríguez Portal JA.   +2 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Influence of alcohol-serving venue characteristics on yield of HIV status-neutral screening in rural East Africa. [PDF]

PLOS Glob Public Health
Litunya J, Beesiga B, Nakato JZ, Mwango J, Marson K, Mugoma EW, Temple J, Agaba P, Kabami J, Kakande E, Hahn JA, Camlin CS, Shade SB, Petersen ML, Havlir DV, Kamya MR, Balzer LB, Ayieko J, Chamie G.   +18 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Ex Libris Joannis Marini Proust? in Paris Curia Patron

EX LIBRIS JOANNIS MARINI PROUST? IN PARIS CURIA PATRON Ex Libris Joannis Marini Proust? in Paris Curia Patron ( -

core  

Right Ventricular Apical Hypoplasia With a Novel Morphologic Presentation: The "Christmas Hat" Sign. [PDF]

JACC Case Rep
Meléndez-Ramírez G, Patrón-Chi SA, Figueroa-Galván FS, Alanís-Naranjo JM, González-Nájera MF, Cruz-Marmolejo MÁ, Meave-González A.   +6 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Neuroblastoma-like schwannoma: Case report with histopathologic correlation [PDF]

Biomedica
Caicedo D, Rodríguez N, Vélez R, Rodríguez R, Restrepo R.   +4 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The Prevalence and Risk Factors for at-Risk MASH and Advanced Liver Fibrosis in People With Metabolic Risk Factors in Primary Care. [PDF]

Aliment Pharmacol Ther
Adams LA, Lei S, Calzadilla-Bertot L, Schrader S, Frear S, Zhou C, Heywood SE, Emery J.   +7 more
europepmc   +1 more source