Results 81 to 90 of about 67,421 (252)
El puerto de Barranquilla, en la costa bicefala
, 1989 Martínez Patron ...
Martínez Patron, Harold
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2023 Patron checking books out.https://digitalcommons.sacredheart.edu/libraryhistoryphotos/1016/thumbnail ...
core
Medium: lithographprintssigned."Patron!..." [0000.2005.000.000], Gavarni, PaulArtist and Role: Gavarni, Paul,Extent ...
Gavarni, Paul
core +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The Patron-Client Relationship Patterns In Siwa Lima Fishermen Community, Aru Islands District Maluku, Indonesia. [PDF]
, 2020 The pattern of patron-client relationships in fishing communities in the Aru islands district can be seen from the closeness of fishermen to the capital owners, ranging from fishing operational costs to the costs for fishermen's daily needs.
AGUSTANG., ANDI DODI MAY PUTRA +4 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Art-SanatDuring his reign and beyond, the Seljuk Sultan Ala al-Din Kayqubad was renowned for his power and construction activities. His legacy as the most illustrious ruler of the Seljuk State is evident in records from the Ottoman Period.
Ayşegül Bekmez Yelen
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source