Results 91 to 100 of about 5,433,982 (316)

SteuerLLM: local specialized large language model for German tax law analysis

Scientific Reports
Large language models (LLMs) demonstrate strong general reasoning and language understanding, yet their performance degrades in domains governed by strict formal rules, precise terminology, and legally binding structure.
Sebastian Wind, Jeta Sopa, Laurin Schmid, Quirin Jackl, Sebastian Kiefer, Fei Wu, Martin Mayr, Harald Köstler, Gerhard Wellein, Andreas Maier, Soroosh Tayebi Arasteh   +10 more
doaj   +1 more source

Longitudinal changes of BOLD-CSF coupling and its association with the clinical assessments in subcortical ischemic stroke

Brain Research Bulletin
Purpose: Stroke is a leading cause of long-term disability globally, with motor deficits being the most prevalent and disabling consequence. However, the neural mechanisms underlying post-stroke motor recovery remain poorly understood.
Yongxin Li, Xuan Zhou
doaj   +1 more source

Kimono-style breakfast jacket, 1919

, 1919
Pattern No. 4821: Jacket is cut kimono fashion with a rolling collar, apron tunic-like front, and ribbon sash that ties at the left. Collar, sleeves, and lower edge of the jacket are "trimmed with deep plaitings of the material." Worn over a simple skirt.
Vogue Pattern Service
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Altered static and dynamic functional connectivity of the default mode network across epilepsy subtypes in children: A resting-state fMRI study

Neurobiology of Disease
Background: Epilepsy is a chronic neurologic disorder characterized by abnormal functioning of brain networks, making it a complex research topic. Recent advancements in neuroimaging technology offer an effective approach to unraveling the intricacies of
Yongxin Li, Yun Ran, Maohua Yao, Qian Chen   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Real-Time Tunnel Crack Analysis System via Deep Learning

IEEE Access, 2019
Cracks in the tunnel become an unavoidable problem in tunnel construction and tunnel using. Cracks will affect the stability of the tunnel and have a negative impact on the operation of the train.
Qing Song, Yingqi Wu, Xueshi Xin, Lu Yang, Min Yang, Hongming Chen, Chun Liu, Mengjie Hu, Xuesong Chai, Jianchao Li   +9 more
doaj   +1 more source

Short sports cape with a rolling collar, 1919

, 1919
Pattern No. 4734: Sash is "finished with embroidered arrows and ties at the center front." Rolled collar is "faced with contrasting material." Arm holes are finished with embroidered arrows. Narrow belt is attached at the sides and "passes under the cape
Vogue Pattern Service
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source