Results 231 to 240 of about 9,950,632 (301)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dietary inflammatory index and unfavorable dietary patterns associated with ischemic stroke in China. [PDF]

Asia Pac J Clin Nutr
Xu Q, Chen Q, Zhuang Y, Zhou L, Shen L, Li T, Hu Z, Zhang R, Su D, Feng L.   +9 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Patterns of Language and Visuospatial Lateralisation and Cognitive Ability in Young Children Aged 4-7 Years. [PDF]

Dev Sci
Quin-Conroy JE, Bayliss DM, Badcock NA.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Risk Factors for Recurrence of the Anti-Synthetase Syndrome Related Interstitial Lung Disease. [PDF]

Immun Inflamm Dis
Ren ZY, Yang X, Yang J, Kou P, Tang XK.
europepmc   +1 more source

Electrokinetic Potential of Basic Zinc Sulfate and of Products of Its Ion Exchange. [PDF]

Molecules
Skupiński S, Kalbarczyk M, Kamiński D, Kosmulski M.   +3 more
europepmc   +1 more source

Analysis of Filler Spread: Facial Retinacula Play a Prominent Role. [PDF]

Dermatol Surg
Schelke L, Harris S, Cerón Bohórquez JM, Lowrey N, Cartier H, Wortsman X, Cotofana S, Velthuis P.   +7 more
europepmc   +1 more source

<i>LaueMatching</i>: an approach for rapid and robust indexing of Laue diffraction patterns. [PDF]

J Appl Crystallogr
Sharma H, Sheyfer D, Harder R, Tischler JZ.   +3 more
europepmc   +1 more source