Results 201 to 210 of about 2,233,900 (268)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Interleukin 6 as a Treatment Target for Depression: A Proof-of-Concept Randomized Clinical Trial.

open access: yesJAMA Psychiatry
Foley ÉM   +7 more
europepmc   +1 more source

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