Results 141 to 150 of about 13,292,654 (316)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Coat-frock with waistcoat, 1919
, 1919 Pattern No. 4780: Waistcoat is trimmed along the edges with braid and down the center with a row of small buttons. Lower edge of the collared, belted blouse "turns up to form a deep cuff which is held in place at the center back with three buttons." Bell-
Vogue Pattern Service
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Misses' coat-frock with sleeveless underblouse, 1919
, 1919 Pattern No. 4758: Underblouse with a shallow "modesty" trimmed with "narrow ruffles of organdie." Neckline and hem of blouse are trimmed with contrasting material. Narrow-collared waistcoat is finished along the back seams with buttons.
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Frock with set-in side sections, 1920
, 1920 Pattern No. 4691: Shirtwaist with bias-cut sleeves, frilling at the neckline, and set-in sections that are "cut sufficiently long to turn up, forming pockets with the skirt at either side." Belt is tied at the center back, and shirtwaist and skirt are ...
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Coat with set-in waistcoat and simple skirt, 1919
, 1919 Pattern No. 4670-71: Double-collared coat trimmed in braid with shirred vest, set-in pockets, and bell sleeves gathered at the wrist. Hobble skirt trimmed with braid.
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