Results 71 to 80 of about 2,397,910 (315)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

MODEL PENINGKATAN POLA KERJA KERAS MELALUI RELIGIOSITY, MOTIVASI INTRINSIK DAN MOTIVASI EKSTRINSIK (Pada PT. Bank Muamalat Indonesia Cabang Kudus)

open access: yesJurnal Ekonomi dan Bisnis, 2017
The purpose of this study is to describe and analyze the effect of religioustic on the pattern of hard work through the intrinsic motivativation and ekstrinsic motivation. And create a development model on the pattern of hard work.
Ahmed Ainul Fuadie El Hakiem
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

NSAIDs: Patterns of Usage and Side Effects

open access: yesHospital Practice, 1989
For best results in patients with arthritic disease, three major protocols are cardinal. The first is adequate dosage—i.e., relatively high anti-inflammatory levels. The second is to give the drug a reasonable trial—three or four weeks. Finally, although the NSAIDs are generally similar, pharmacologic differences among them may be clinically pertinent.
openaire   +3 more sources

Frock with blouse in Eton jacket effect, 1919

open access: yes, 1919
Pattern No. 4771: Blouse with "narrow turn-over collar" and cuffed three-quarter length sleeves. Fullness of skirt is gathered to the lower edges of the blouse; in front, the blouse hangs over the skirt.
Vogue Pattern Service
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Plaited skirts, 1919

open access: yes, 1919
Pattern No. 4660: "Two-piece plaited skirt with simulated panel effect." "Separate girdle is buttoned with two buttons at the center front." Pattern No.
Vogue Pattern Service
core  

The multifocal pattern electroretinogram in chloroquine retinopathy [PDF]

open access: yes, 2004
Purpose: Optimal screening for ocular toxicity caused by chloroquine and hydroxychloroquine is still controversial. With the multifocal pattern electroretinogram (mfPERG), a new electrophysiological technique has recently become available to detect early
Stiefelmeyer, S.   +4 more
core   +1 more source

Expected Pattern Effect and Differential Expected Pattern Effect determine the significance of feature patterns such as transcription factor motifs or transcription factor grammar for multitask models.

open access: yes, 2021
(A) Comparison of interpretation methods shows 3 categories of interpretation methods for deep learning models based on input. Some methods operate on an individual sequence input, model pair, others turn learned convolutional filters into DNA sequence ...
Jennifer Hammelman (10939618)   +1 more
core   +1 more source

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