Results 211 to 220 of about 11,592,948 (265)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

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The effectiveness of groups recognizing patterns

International Journal of Human-Computer Studies, 2003
An experiment was conducted in which groups made resource allocation decisions while physically dispersed and supported with a shared virtual work surface (What You See Is What I See--WYSIWIS). The task required groups to recognize patterns of information and collaborate to allocate their resources appropriately. The experimental treatment involved the
Stephen C. Hayne, C. A. P. Smith, Dan Turk   +2 more
openaire   +2 more sources

Fatigue Effects on Patterns of Movement

Ergonomics, 1971
The standing broad jump and four other gross body movements were analysed by colour-coded multiple-image photography before and after three kinds of fatigue-inducing exercise. For each movement marked individual differences in style of performance were found which tended to persist despite the effects of fatigue.
F P, Jones, J A, Hanson
openaire   +2 more sources

Laterality Effects for Tactile Patterns

International Journal of Neuroscience, 1994
A series of studies was carried out to investigate laterality effects in the discrimination of tactile patterns presented to the fingertips of right-handed subjects. When both hands were stimulated simultaneously, a small right-hand advantage (RHA) was observed for a sequential task and a small left-hand advantage (LHA) was found for a spatial task ...
K, Minami, V, Kay, M P, Bryden, T, Free
openaire   +2 more sources

Bad Effects of Patterning

Pediatrics, 1983
To the Editor.— I would like to commend the American Academy of Pediatrics for its updated and strong statement against the "patterning" treatment of neurologically handicapped children.1 Certainly one of the problems with the promoters of this type of treatment has been their insistence that the therapy be carried out 365
openaire   +2 more sources

Patterns for Effectively Documenting Frameworks

2011
Good design and implementation are necessary but not sufficient prerequisites for successfully reusing object-oriented frameworks. Although not always recognized, good documentation is crucial for effective framework reuse, and often hard, costly, and tiresome, coming with many issues, especially when we are not aware of the key problems and respective
Ademar Aguiar, Gabriel David
openaire   +2 more sources

Effects of disorder in pattern formation

Physical Review E, 1993
The interplay between localization and nonlinearity is investigated for a modified Swift-Hohenberg equation. We introduced a spatially stochastic contribution ηξ(x) in the control parameter that mimics, for instance, the essential effects of irregularities at the top and bottom plate in Rayleigh-Benard convection experiments.
, Zimmermann, , Seesselberg, , Petruccione   +2 more
openaire   +2 more sources