Results 161 to 170 of about 29,540 (218)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

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The effectiveness of groups recognizing patterns

International Journal of Human-Computer Studies, 2003
An experiment was conducted in which groups made resource allocation decisions while physically dispersed and supported with a shared virtual work surface (What You See Is What I See--WYSIWIS). The task required groups to recognize patterns of information and collaborate to allocate their resources appropriately. The experimental treatment involved the
Stephen C. Hayne, C. A. P. Smith, Dan Turk   +2 more
openaire   +2 more sources

Fatigue Effects on Patterns of Movement

Ergonomics, 1971
The standing broad jump and four other gross body movements were analysed by colour-coded multiple-image photography before and after three kinds of fatigue-inducing exercise. For each movement marked individual differences in style of performance were found which tended to persist despite the effects of fatigue.
F P, Jones, J A, Hanson
openaire   +2 more sources

Laterality Effects for Tactile Patterns

International Journal of Neuroscience, 1994
A series of studies was carried out to investigate laterality effects in the discrimination of tactile patterns presented to the fingertips of right-handed subjects. When both hands were stimulated simultaneously, a small right-hand advantage (RHA) was observed for a sequential task and a small left-hand advantage (LHA) was found for a spatial task ...
K, Minami, V, Kay, M P, Bryden, T, Free
openaire   +2 more sources

Bad Effects of Patterning

Pediatrics, 1983
To the Editor.— I would like to commend the American Academy of Pediatrics for its updated and strong statement against the "patterning" treatment of neurologically handicapped children.1 Certainly one of the problems with the promoters of this type of treatment has been their insistence that the therapy be carried out 365
openaire   +2 more sources

Patterns for Effectively Documenting Frameworks

2011
Good design and implementation are necessary but not sufficient prerequisites for successfully reusing object-oriented frameworks. Although not always recognized, good documentation is crucial for effective framework reuse, and often hard, costly, and tiresome, coming with many issues, especially when we are not aware of the key problems and respective
Ademar Aguiar, Gabriel David
openaire   +2 more sources

Effects of disorder in pattern formation

Physical Review E, 1993
The interplay between localization and nonlinearity is investigated for a modified Swift-Hohenberg equation. We introduced a spatially stochastic contribution ηξ(x) in the control parameter that mimics, for instance, the essential effects of irregularities at the top and bottom plate in Rayleigh-Benard convection experiments.
, Zimmermann, , Seesselberg, , Petruccione   +2 more
openaire   +2 more sources